Changes in morphogenesis and carotenogenesis to influence polygalacturonase secretion in Aspergillus carbonarius mutant
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Microbiology"
DOI: 10.1007/s00203-020-01838-7
Abstract: Mycelial morphogenesis and the production of fungal secretory proteins are still largely unknown. A mutant strain of Aspergillus carbonarius UV-10046 produced abundant polygalacturonase (PG) along with partially saturated canthaxanthin (PSC) at low pH conditions. In… read more here.
Keywords: secretion; polygalacturonase; changes morphogenesis; mutant ... See more keywords
Integration of multiple stimuli-sensing systems to regulate HrpS and type III secretion system in Erwinia amylovora
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Genetics and Genomics"
DOI: 10.1007/s00438-017-1376-3
Abstract: The bacterial enhancer binding protein (bEBP) HrpS is essential for Erwinia amylovora virulence by activating the type III secretion system (T3SS). However, how the hrpS gene is regulated remains poorly understood in E. amylovora. In… read more here.
Keywords: erwinia amylovora; system; iii secretion; mutant ... See more keywords
Isolation and characterization of a high-growth-rate strain in Pyropia yezoensis induced by ethyl methane sulfonate
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Applied Phycology"
DOI: 10.1007/s10811-018-1426-1
Abstract: Chemical treatment is a powerful way to induce mutagenesis and has been applied in various studies. Here we describe the isolation of a high-growth-rate mutant Pyropia yezoensis induced by ethyl methane sulfonate (EMS) exposure. The… read more here.
Keywords: high growth; mutant; growth rate; strain ... See more keywords
Vitamin C and Vitamin D3 show strong binding with the amyloidogenic region of G555F mutant of Fibrinogen A alpha-chain associated with renal amyloidosis: proposed possible therapeutic intervention.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular diversity"
DOI: 10.1007/s11030-021-10205-7
Abstract: G555F mutant of Fibrinogen A alpha-chain (FGA) is reported to be associated with kidney amyloidosis. In the current study, we have modelled the G555F mutant and examined the mutation's effect on the structural and functional… read more here.
Keywords: amyloidogenic region; mutant; amyloidosis; g555f mutant ... See more keywords
The inability of Bacillus licheniformis perR mutant to grow is mainly due to the lack of PerR-mediated fur repression
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Microbiology"
DOI: 10.1007/s12275-017-7051-x
Abstract: PerR, a member of Fur family protein, is a metal-dependent H2O2 sensing transcription factor that regulates genes involved in peroxide stress response. Industrially important bacterium Bacillus licheniformis contains three PerR-like proteins (PerRBL, PerR2, and PerR3)… read more here.
Keywords: perr; licheniformis perr; bacillus licheniformis; mutant ... See more keywords
Molecular mechanisms underlying enhanced hemichannel function of a cataract-associated Cx50 mutant.
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical journal"
DOI: 10.1016/j.bpj.2021.11.004
Abstract: Connexin-50 (Cx50) is among the most frequently mutated genes associated with congenital cataracts. While most of these disease-linked variants cause loss-of-function due to misfolding or aberrant trafficking, others directly alter channel properties. The mechanistic bases… read more here.
Keywords: enhanced hemichannel; hemichannel; mutant; molecular mechanisms ... See more keywords
PrsA contributes to Streptococcus suis serotype 2 pathogenicity by modulating secretion of selected virulence factors.
Sign Up to like & getrecommendations! Published in 2019 at "Veterinary microbiology"
DOI: 10.1016/j.vetmic.2019.07.027
Abstract: Streptococcus suis serotype 2 (S. suis 2) is a major zoonotic pathogen. Parvulin-type peptidyl-prolyl isomerase (PrsA) in S. suis 2 is found surface-associated, pro-inflammatory and cytotoxic. To further explore the roles of PrsA in S.… read more here.
Keywords: mutant; streptococcus suis; prsa; suis serotype ... See more keywords
Construction of a mutant of Actinoplanes sp. N902-109 that produces a new rapamycin analog.
Sign Up to like & getrecommendations! Published in 2018 at "Chinese journal of natural medicines"
DOI: 10.1016/s1875-5364(18)30049-9
Abstract: In the present study, we introduced point mutations into Ac_rapA which encodes a polyketide synthase responsible for rapamycin biosynthesis in Actinoplanes sp. N902-109, in order to construct a mutant with an inactivated enoylreductase (ER) domain,… read more here.
Keywords: n902 109; actinoplanes n902; rapamycin analog; mutant ... See more keywords
Characterization of an Exceptional Fungal Mutant Enables the Discovery of the Specific Regulator of a Silent PKS-NRPS Hybrid Biosynthetic Pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c03550
Abstract: Filamentous fungi produce a great variety of bioactive secondary metabolites essential for their biotic interactions. Here, we characterized an exceptional Trichoderma mutant overproducing harzianic acids (HAs) with exclusively highly antifungal activity against numerous fungi from… read more here.
Keywords: fungal mutant; enables discovery; mutant; characterization exceptional ... See more keywords
Discovery of a Potent Dual Inhibitor of Wild-Type and Mutant Respiratory Syncytial Virus Fusion Proteins.
Sign Up to like & getrecommendations! Published in 2020 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.0c00008
Abstract: A novel series of macrocyclic pyrazolo[1,5-a]pyrimidine derivatives as respiratory syncytial virus (RSV) fusion glycoprotein (F protein) inhibitors were designed and synthesized based on docking studies of acyclic inhibitors. This effort resulted in the discovery of… read more here.
Keywords: respiratory syncytial; syncytial virus; mutant; type mutant ... See more keywords
Imaging pH Dynamics Simultaneously in Two Cellular Compartments Using a Ratiometric pH-Sensitive Mutant of mCherry
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DOI: 10.1021/acsomega.8b00655
Abstract: The regulation of pH is essential for proper organelle function, and organelle-specific changes in pH often reflect the dynamics of physiological signaling and metabolism. For example, mitochondrial energy production depends on the proton gradient maintained… read more here.
Keywords: simultaneously two; fluorescent; imaging dynamics; two cellular ... See more keywords