Targeting of super-enhancers and mutant BRAF can suppress growth of BRAF-mutant colon cancer cells via repression of MAPK signaling pathway.
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DOI: 10.1016/j.canlet.2017.05.017
Abstract: Bromodomain and extra-terminal (BET) inhibitors suppress super-enhancers and show cytotoxicity against multiple types of tumors. However, early clinical trials with BET inhibitors showed severe hematopoietic toxicities, highlighting the need for sensitive tumors and rational combination… read more here.
Keywords: signaling pathway; mapk signaling; mutant braf; colon cancer ... See more keywords