Fight mutant cancer cells by … making more mutations?
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.abq6111
Abstract: Chemotherapies that induce new DNA errors may help unleash the immune system on tumors. read more here.
Keywords: cells making; cancer cells; fight mutant; mutant cancer ... See more keywords
Abstract 2008: Induced macropinocytosis by DNA-PK inhibitor for KRAS mutant cancer targeting of albumin-binding peptide drug conjugate
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2008
Abstract: Although Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) is the most well-known tumor driver gene with the highest mutation rate in several types of cancer, there is no effective mutant KRAS targeting drug yet. Recent… read more here.
Keywords: mutant cancer; dna inhibitor; kras mutant; tumor ... See more keywords
Exploiting macropinocytosis for drug delivery into KRAS mutant cancer
Sign Up to like & getrecommendations! Published in 2022 at "Theranostics"
DOI: 10.7150/thno.67889
Abstract: KRAS mutations are one of the most common gene mutations linked to cancer, presenting in approximately 25% of all tumors, especially pancreatic, lung, and colorectal cancers. Mutant KRAS has long been considered an undruggable target,… read more here.
Keywords: mutant cancer; delivery; kras mutant; drug delivery ... See more keywords