ACTION: a randomized phase 3 study of ONC201 (dordaviprone) in patients with newly diagnosed H3 K27M-mutant diffuse glioma
Sign Up to like & getrecommendations! Published in 2024 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noae031
Abstract: Abstract Background H3 K27M-mutant diffuse glioma primarily affects children and young adults, is associated with a poor prognosis, and no effective systemic therapy is currently available. ONC201 (dordaviprone) has previously demonstrated efficacy in patients with… read more here.
Keywords: mutant diffuse; k27m mutant; diffuse glioma; glioma ... See more keywords
CTP-15. Dordaviprone (ONC201) in a pediatric patient with recurrent H3 K27M-mutant diffuse glioma and leptomeningeal disease
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaf201.0587
Abstract: H3 K27M-mutant diffuse midline glioma (DMG) is a molecularly and clinically distinct subtype of CNS WHO Grade 4 glioma with a median overall survival (mOS) of ~1 year from diagnosis. Leptomeningeal disease (LMD) has been… read more here.
Keywords: dordaviprone; mutant diffuse; k27m; k27m mutant ... See more keywords
Prolonged survival in a patient with a cervical spine H3K27M-mutant diffuse midline glioma
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DOI: 10.1136/bcr-2019-231424
Abstract: We report a case of prolonged survival in a patient with known cervical intramedullary H3K27M-mutant diffuse midline glioma. A 39-year-old man presented for evaluation with several months of progressive upper extremity pain and weakness. MRI… read more here.
Keywords: survival patient; midline glioma; diffuse midline; prolonged survival ... See more keywords
Abstract CT060: ACTION: A randomized phase 3 study of dordaviprone (ONC201) in patients with newly diagnosed H3 K27M-mutant diffuse glioma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-ct060
Abstract: Background: H3 K27M-mutant diffuse midline glioma is a universally fatal malignancy primarily affecting children and young adults. While radiotherapy (RT) provides transient benefit, no effective systemic therapy is currently available and current standard of care… read more here.
Keywords: mutant diffuse; k27m mutant; glioma; dordaviprone ... See more keywords
Abstract 4731: Targeting Lon protease as novel strategy to treat aggressive IDH mutant diffuse malignant astrocytoma
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-4731
Abstract: While isocitrate dehydrogenase (IDH) wild-type and mutant malignant astrocytoma (IDHwt, IDHmt) are diffuse CNS tumors that have a high degree of parallelism with one another, including microvascular proliferation and necrosis, the IDHwt tumors clinically presents… read more here.
Keywords: diffuse; idh; malignant astrocytoma; mutant diffuse ... See more keywords
Single-cell RNA sequencing of anaplastic ependymoma and H3K27M-mutant diffuse midline glioma
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DOI: 10.1186/s12883-024-03558-7
Abstract: Anaplastic ependymoma and H3K27M-mutant diffuse midline glioma are two common subtypes of brain tumors with poor long-term prognosis. The present study analyzed and compared the differences in cell types between two tumors by single-cell RNA… read more here.
Keywords: mutant diffuse; anaplastic ependymoma; midline glioma; cell ... See more keywords
Anatomic Staging of H3 G34-Mutant Diffuse Hemispheric Glioma.
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DOI: 10.1212/wnl.0000000000213861
Abstract: OBJECTIVES H3 G34-mutant diffuse hemispheric gliomas are rare, aggressive primary brain tumors predominantly affecting young patients. We investigated the prognostic value of anatomic staging (AS)-a system previously validated in adult-type diffuse gliomas-in this molecularly distinct… read more here.
Keywords: anatomic staging; mutant diffuse; diffuse; diffuse hemispheric ... See more keywords
Exploiting Gangliosides for the Therapy of Ewing’s Sarcoma and H3K27M-Mutant Diffuse Midline Glioma
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DOI: 10.3390/cancers13030520
Abstract: Simple Summary Osteosarcoma, Ewing’s sarcoma, and H3K27M-mutant diffuse midline glioma are rare but aggressive malignancies occurring mainly in children. Due to their rareness and often fatal course, drug development is challenging. Here, we repurposed the… read more here.
Keywords: gd2; h3k27m; ewing sarcoma; h3k27m mutant ... See more keywords