Prolonged survival in a patient with a cervical spine H3K27M-mutant diffuse midline glioma
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DOI: 10.1136/bcr-2019-231424
Abstract: We report a case of prolonged survival in a patient with known cervical intramedullary H3K27M-mutant diffuse midline glioma. A 39-year-old man presented for evaluation with several months of progressive upper extremity pain and weakness. MRI… read more here.
Keywords: survival patient; midline glioma; diffuse midline; prolonged survival ... See more keywords
Abstract CT060: ACTION: A randomized phase 3 study of dordaviprone (ONC201) in patients with newly diagnosed H3 K27M-mutant diffuse glioma
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DOI: 10.1158/1538-7445.am2023-ct060
Abstract: Background: H3 K27M-mutant diffuse midline glioma is a universally fatal malignancy primarily affecting children and young adults. While radiotherapy (RT) provides transient benefit, no effective systemic therapy is currently available and current standard of care… read more here.
Keywords: mutant diffuse; k27m mutant; glioma; dordaviprone ... See more keywords
Exploiting Gangliosides for the Therapy of Ewing’s Sarcoma and H3K27M-Mutant Diffuse Midline Glioma
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DOI: 10.3390/cancers13030520
Abstract: Simple Summary Osteosarcoma, Ewing’s sarcoma, and H3K27M-mutant diffuse midline glioma are rare but aggressive malignancies occurring mainly in children. Due to their rareness and often fatal course, drug development is challenging. Here, we repurposed the… read more here.
Keywords: gd2; h3k27m; ewing sarcoma; h3k27m mutant ... See more keywords