Structural Optimization and MD Simulation Study of Benzimidazole Derivatives as Potent Mutant FLT3 Kinase Inhibitors Targeting AML
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DOI: 10.1002/ardp.70002
Abstract: Acute myeloid leukemia (AML) is an aggressive hematological malignancy with poor survival rates in adults, posing a significant economic burden. FMSâlike tyrosine kinase 3 (FLT3) mutations are linked to poor prognosis in AML and resistance… read more here.
Keywords: potent mutant; mutant flt3; flt3; cell ... See more keywords
BETing on rational combination therapy in mutant FLT3 acute myeloid leukemia
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DOI: 10.3324/haematol.2020.274753
Abstract: therapy in young mice. J Immunol. 2010;184(11):6014-6024. 19.Abou Dalle I, Paranal R, Zarka J, et al. Impact of luteinizing hormone suppression on hematopoietic recovery after intensive chemotherapy in patients with leukemia. Haematologica. 2021;106(4):1097-1105. 20. Poorvu… read more here.
Keywords: mutant flt3; rational combination; beting rational; therapy ... See more keywords