Evolution of inhibitor-resistant natural mutant forms of HIV-1 protease probed by pre-steady state kinetic analysis.
Sign Up to like & getrecommendations! Published in 2017 at "Biochimie"
DOI: 10.1016/j.biochi.2017.08.014
Abstract: Pre-steady state kinetic analysis of mechanistic features of substrate binding and processing is crucial for insight into the evolution of inhibitor-resistant forms of HIV-1 protease. These data may provide a correct vector for rational drug… read more here.
Keywords: inhibitor; protease; steady state; pre steady ... See more keywords
5th Update on Fabry Nephropathy: Biomarkers, Progression and Treatment Opportunities. April 25-27, 2017, Mexico City, Mexico: Abstracts
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DOI: 10.1159/000475511
Abstract: s Nephron 2017;136:163–182 DOI: 10.1159/000475511 168 frame insertions/deletions, and multiple-site missense mutations may result in mutant forms amenable to the mechanism of action of migalastat. However, mutations that impair the synthesis of α-Gal A, severely… read more here.
Keywords: migalastat; hek assay; site; mutant forms ... See more keywords