Telocytes are the physiological counterpart of inflammatory fibroid polyps and PDGFRA‐mutant GISTs
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DOI: 10.1111/jcmm.13748
Abstract: PDGFRA mutations in the gastrointestinal (GI) tract can cause GI stromal tumour (GIST) and inflammatory fibroid polyp (IFP). Hitherto no cell type has been identified as a physiological counterpart of the latter, while interstitial Cajal… read more here.
Keywords: inflammatory fibroid; pdgfra; mutant gists; physiological counterpart ... See more keywords
KIT Exon 9-Mutated Gastrointestinal Stromal Tumours: Biology and Treatment
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DOI: 10.1159/000521751
Abstract: Background: The majority of gastroinstestinal stromal tumours (GISTs) harbour oncogenic mutations in the gene encoding for the tyrosine kinase (TK) KIT. The most common mutations are found in exon 11, followed by mutations in exon… read more here.
Keywords: kit exon; exon mutant; mutant gists; biology ... See more keywords
miRNA Expression May Have Implications for Immunotherapy in PDGFRA Mutant GISTs
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DOI: 10.3390/ijms232012248
Abstract: Gastrointestinal stromal tumors (GISTs) harboring mutations in the PDGFRA gene occur in only about 5–7% of patients. The most common PDGFRA mutation is exon 18 D842V, which is correlated with specific clinico-pathological features compared to… read more here.
Keywords: d842v; expression; expression may; pdgfra ... See more keywords