Isocitrate dehydrogenase‐mutant glioma: Evolving clinical and therapeutic implications
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DOI: 10.1002/cncr.31039
Abstract: The metabolic genes isocitrate dehydrogenase 1 (IDH1) and IDH2 are commonly mutated in low‐grade glioma and in a subset of glioblastoma. These mutations co‐occur with other recurrent molecular alterations, including 1p/19q codeletions and tumor suppressor… read more here.
Keywords: glioma; isocitrate dehydrogenase; idh; mutant glioma ... See more keywords
Intraoperative detection of IDH‐mutant glioma using fluorescence lifetime imaging
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DOI: 10.1002/jbio.202200291
Abstract: Identifying isocitrate dehydrogenase (IDH)‐mutation and glioma subtype during surgery instead of days later can aid in modifying tumor resection strategies for better survival outcomes. We report intraoperative identification of IDH‐mutant glioma (N = 12 patients)… read more here.
Keywords: idh mutant; mutant glioma; glioma; fluorescence lifetime ... See more keywords
Multi-institutional study of the frequency, genomic landscape and outcome of IDH-mutant glioma in paediatrics.
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DOI: 10.1093/neuonc/noac132
Abstract: BACKGROUND The incidence and biology of IDH1/2 mutations in pediatric gliomas are unclear. Notably, current treatment approaches by pediatric and adult providers vary significantly. We describe the frequency and clinical outcomes of IDH1/2-mutant gliomas in… read more here.
Keywords: mutant glioma; idh1 mutant; multi institutional; frequency ... See more keywords
Abstract 3414: The pan-RAF inhibitor tovorafenib suppresses NF1-mutant glioma through upregulation of FOXO1 and triggering of oncogene-induced senescence
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DOI: 10.1158/1538-7445.am2023-3414
Abstract: Pediatric low-grade glioma (pLGG) is the most common childhood brain tumor. Patients with pLGG often have significant lifelong disabilities due to the location of the tumor and tumor treatments, including surgery, chemotherapy, and radiation. The… read more here.
Keywords: mutant glioma; tovorafenib; senescence; foxo1 ... See more keywords
(R)-2HG Inhibits the BCAT Transaminase in IDH-Mutant Glioma.
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DOI: 10.1158/2159-8290.cd-rw2018-162
Abstract: BCAT inactivation renders IDH-mutant cells dependent on glutaminase for glutamate and glutathione synthesis. read more here.
Keywords: bcat transaminase; 2hg inhibits; inhibits bcat; idh mutant ... See more keywords