P04.12 Characteristics of IDH-mutant gliomas with non-canonical IDH mutations
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz126.107
Abstract: About 10% of IDH-mutant gliomas harbor non-canonical IDH mutations (non-R132H IDH1 and IDH2 mutations). The aim of the present study was to analyze the characteristics of these gliomas in comparison to those of IDH1 R132H… read more here.
Keywords: mutant gliomas; gliomas; canonical idh; gliomas non ... See more keywords
Abstract 3479: Modeling epigenetic lesions that cause gliomas
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3479
Abstract: Epigenetic lesions that disrupt gene regulatory elements and expression are increasingly recognized as potential drivers of human cancers. However, we currently lack the in vitro and in vivo models required to functionally validate such lesions… read more here.
Keywords: idh mutant; epigenetic lesions; gliomas; insulator ... See more keywords
ATRX regulates glial identity and the tumor microenvironment in IDH-mutant glioma
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DOI: 10.1186/s13059-021-02535-4
Abstract: Background Recent single-cell transcriptomic studies report that IDH-mutant gliomas share a common hierarchy of cellular phenotypes, independent of genetic subtype. However, the genetic differences between IDH-mutant glioma subtypes are prognostic, predictive of response to chemotherapy,… read more here.
Keywords: mutant gliomas; idh mutant; glioma; atrx ... See more keywords
Altered metabolic landscape in IDH‐mutant gliomas affects phospholipid, energy, and oxidative stress pathways
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DOI: 10.15252/emmm.201707729
Abstract: Heterozygous mutations in NADP‐dependent isocitrate dehydrogenases (IDH) define the large majority of diffuse gliomas and are associated with hypermethylation of DNA and chromatin. The metabolic dysregulations imposed by these mutations, whether dependent or not on… read more here.
Keywords: mutant gliomas; gliomas; energy; idh mutant ... See more keywords