Abstract 1261: Mutant IDH-mediated suppression of the Th17 lineage in glioma: Biologic impact and therapeutic potential
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1261
Abstract: Great excitement has been generated around the identification of tumor-specific hotspot mutations in isocitrate dehydrogenase I (IDH1) as they are the first potential therapeutic targets of low grade gliomas that have been identified in the… read more here.
Keywords: mutant idh; impact; th17; glioma ... See more keywords
Mutant IDH regulates glycogen metabolism from early cartilage development to malignant chondrosarcoma formation.
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DOI: 10.2139/ssrn.4229509
Abstract: Chondrosarcomas are the most common malignancy of cartilage and are associated with somatic mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 genes. Somatic IDH mutations are also found in its benign precursor lesion, enchondromas, suggesting… read more here.
Keywords: glycogen metabolism; idh1; mutant idh; cartilage ... See more keywords
Mutant IDH in Gliomas: Role in Cancer and Treatment Options
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DOI: 10.3390/cancers15112883
Abstract: Simple Summary Isocitrate dehydrogenase (IDH) is the most mutated metabolic gene in human cancer. Mutations in this gene have been identified in a high percentage of gliomas, in acute myeloid leukemia (AML) and in many… read more here.
Keywords: idh mutant; mutant idh; idh gliomas; gliomas role ... See more keywords