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   Articles with "mutant kras" as a keyword



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Mutant KRAS Drives Immune Evasion by Sensitizing Cytotoxic T‐Cells to Activation‐Induced Cell Death in Colorectal Cancer

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recommendations! Published in 2023 at "Advanced Science"

DOI: 10.1002/advs.202203757

Abstract: The roles of oncogenic KRAS in tumor immune evasion remain poorly understood. Here, mutant KRAS is identified as a key driver of tumor immune evasion in colorectal cancer (CRC). In human CRC specimens, a significant… read more here.

Keywords: cell; immune evasion; mutant kras; colorectal cancer ... See more keywords
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A mutant KRAS‐induced factor REG4 promotes cancer stem cell properties via Wnt/β‐catenin signaling

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recommendations! Published in 2019 at "International Journal of Cancer"

DOI: 10.1002/ijc.32728

Abstract: Mutant KRAS provides a driving force for enhancement of cancer stem cells (CSCs) characteristics contributing transformation of colorectal cancer (CRC) cells harboring adenomatous polyposis coli (APC) mutations. Here, we identified the factors mediating the promotion… read more here.

Keywords: cancer stem; mutant kras; reg4; stem cell ... See more keywords
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Extracellular vesicles are the primary source of blood‐borne tumour‐derived mutant KRAS DNA early in pancreatic cancer

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recommendations! Published in 2021 at "Journal of Extracellular Vesicles"

DOI: 10.1002/jev2.12142

Abstract: Abstract Up to now, the field of liquid biopsies has focused on circulating tumour DNA and cells, though extracellular vesicles (EVs) have been of increasing interest in recent years. Thus, reported sources of tumour‐derived nucleic… read more here.

Keywords: extracellular vesicles; mutant kras; kras dna; tumour derived ... See more keywords
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An extracellular vesicular mutant KRAS‐associated protein complex promotes lung inflammation and tumor growth

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recommendations! Published in 2023 at "Journal of Extracellular Vesicles"

DOI: 10.1002/jev2.12307

Abstract: Abstract Extracellular vesicles (EVs) contain more than 100 proteins. Whether there are EVs proteins that act as an ‘organiser’ of protein networks to generate a new or different biological effect from that identified in EV‐producing… read more here.

Keywords: protein complex; inflammation; mutant kras; lung inflammation ... See more keywords
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ARF6, induced by mutant Kras, promotes proliferation and Warburg effect in pancreatic cancer.

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recommendations! Published in 2017 at "Cancer letters"

DOI: 10.1016/j.canlet.2016.12.014

Abstract: Though significant progress has been made in the availability of diagnostic techniques and treatment strategies, pancreatic cancer remains a disease of high mortality rates. Therefore, there is an urgent need for a better understanding of… read more here.

Keywords: mutant kras; arf6; pancreatic cancer; warburg effect ... See more keywords
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A CRISPR-Cas13a system for efficient and specific therapeutic targeting of mutant KRAS for pancreatic cancer treatment.

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recommendations! Published in 2018 at "Cancer letters"

DOI: 10.1016/j.canlet.2018.05.042

Abstract: Mutant KRAS is a known driver oncogene in pancreatic cancer. However, this protein remains an "undruggable" therapeutic target. Inhibiting mutated KRAS expression at the mRNA level is a potentially effective strategy. Recently, a novel CRISPR-Cas… read more here.

Keywords: crispr cas13a; mutant kras; cas13a; cas13a system ... See more keywords
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Modulating Protein-Protein Interactions of the Mitotic Polo-like Kinases to Target Mutant KRAS

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recommendations! Published in 2017 at "Cell Chemical Biology"

DOI: 10.1016/j.chembiol.2017.07.009

Abstract: Summary Mutations activating KRAS underlie many forms of cancer, but are refractory to therapeutic targeting. Here, we develop Poloppin, an inhibitor of protein-protein interactions via the Polo-box domain (PBD) of the mitotic Polo-like kinases (PLKs),… read more here.

Keywords: protein; protein interactions; mutant kras; target mutant ... See more keywords
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Mutant KRAS at the Heart of Tumor Immune Evasion.

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recommendations! Published in 2020 at "Immunity"

DOI: 10.1016/j.immuni.2019.12.013

Abstract: In the search for therapeutic combinations for the treatment of cancer, the pairing of targeted inhibitors of oncogenic driver pathways with immunotherapy has largely been overlooked. In Nature, Canon et al. (2019) describe how the novel… read more here.

Keywords: kras heart; immune evasion; mutant kras; tumor immune ... See more keywords
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IA05 Genomic Underpinnings of Tumor Behavior in in Situ and Early Lung Adenocarcinoma

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recommendations! Published in 2020 at "Journal of Thoracic Oncology"

DOI: 10.1016/j.jtho.2019.12.006

Abstract: Mutations in KRAS are among the most frequent RAS alterations in human cancers and the prevalent driver event in lung adenocarcinoma (LUAD). There are still no effective targeted therapies for KRAS-driven LUAD, although specific KRAS… read more here.

Keywords: dimerization; lung adenocarcinoma; wild type; mutant kras ... See more keywords
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GSK3 suppression upregulates β-catenin and c-Myc to abrogate KRas-dependent tumors

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recommendations! Published in 2018 at "Nature Communications"

DOI: 10.1038/s41467-018-07644-6

Abstract: Mutant KRas is a significant driver of human oncogenesis and confers resistance to therapy, underscoring the need to develop approaches that disable mutant KRas-driven tumors. Because targeting KRas directly has proven difficult, identifying vulnerabilities specific… read more here.

Keywords: vivo growth; dependent tumors; mutant kras; kras dependent ... See more keywords
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High prevalence of mutant KRAS in circulating exosome-derived DNA from early-stage pancreatic cancer patients

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recommendations! Published in 2017 at "Annals of Oncology"

DOI: 10.1093/annonc/mdx004

Abstract: Background Exosomes arise from viable cancer cells and may reflect a different biology than circulating cell-free DNA (cfDNA) shed from dying tissues. We compare exosome-derived DNA (exoDNA) to cfDNA in liquid biopsies of patients with… read more here.

Keywords: pdac patients; mutant kras; early stage; cancer ... See more keywords