Single-cell transcriptome analysis revealed a suppressive tumor immune microenvironment in EGFR mutant lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-003534
Abstract: Backgrounds Immunotherapy is less effective in patients with epidermal growth factor receptor (EGFR) mutant non-small-cell lung cancer (NSCLC). Lower programmed cell death-ligand 1 (PD-L1) expression and tumor mutation burden (TMB) are reported to be the… read more here.
Keywords: egfr; egfr mutant; single cell; mutant luad ... See more keywords
cAMP response element-binding protein mediates immune-evasion of KRAS-mutant lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Lung Cancer"
DOI: 10.1183/23120541.lsc-2021.84
Abstract: Introduction: cAMP response element-binding protein (CREB) mediates proliferative and inflammatory transcription in neurodegeneration and cancer, but its role in malignant immune-evasion is obscure. Objectives: To discover the mechanisms underlying the oncogenic properties of CREB in… read more here.
Keywords: cxcr1; immune evasion; kras mutant; mutant luad ... See more keywords