Combined inhibition of MEK and nuclear ERK translocation has synergistic antitumor activity in melanoma cells
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DOI: 10.1038/s41598-017-16558-0
Abstract: Genetic alterations in BRAF, NRAS and NF1 that activate the ERK cascade, account for over 80% of metastatic melanomas. However, ERK cascade inhibitors have been proven beneficial almost exclusively for BRAF mutant melanomas. One of… read more here.
Keywords: melanoma cells; mutant melanomas; erk1; translocation ... See more keywords