Dendritic cell functions in vivo: A user's guide to current and next‐ generation mutant mouse models
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149513
Abstract: DCs do not just excel in antigen presentation. They orchestrate information transfer from innate to adaptive immunity by sensing and integrating a variety of danger signals, and translating them to naïve T cells, to mount… read more here.
Keywords: mouse; next generation; generation mutant; mouse models ... See more keywords
A spontaneous and novel Pax3 mutant mouse that models Waardenburg syndrome and neural tube defects.
Sign Up to like & getrecommendations! Published in 2017 at "Gene"
DOI: 10.1016/j.gene.2016.12.037
Abstract: BACKGROUND Genes responsible for reduced pigmentation phenotypes in rodents are associated with human developmental defects, such as Waardenburg syndrome, where patients display congenital deafness along with various abnormalities mostly related to neural crest development deficiency.… read more here.
Keywords: pax3; spontaneous novel; waardenburg syndrome; mutant mouse ... See more keywords
An efficient method for generation of bi-allelic null mutant mouse embryonic stem cells and its application for investigating epigenetic modifiers
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx811
Abstract: Abstract Mouse embryonic stem (ES) cells are a popular model system to study biological processes, though uncovering recessive phenotypes requires inactivating both alleles. Building upon resources from the International Knockout Mouse Consortium (IKMC), we developed… read more here.
Keywords: mouse embryonic; mutant mouse; embryonic stem; null mutant ... See more keywords
Nociception in the Glycine Receptor Deficient Mutant Mouse Spastic
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.832490
Abstract: Glycine receptors (GlyRs) are the primary mediators of fast inhibitory transmission in the mammalian spinal cord, where they modulate sensory and motor signaling. Mutations in GlyR genes as well as some other genes underlie the… read more here.
Keywords: mouse spastic; deficient mutant; glycine; mice ... See more keywords
A Dysferlin Exon 32 Nonsense Mutant Mouse Model Shows Pathological Signs of Dysferlinopathy
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11051438
Abstract: Dysferlinopathies are a group of autosomal recessive muscular dystrophies caused by pathogenic variants in the DYSF gene. While several animal models of dysferlinopathy have been developed, most of them involve major disruptions of the Dysf… read more here.
Keywords: nonsense mutant; exon nonsense; dysferlin exon; model ... See more keywords
Polysialylation in a DISC1 Mutant Mouse
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23095207
Abstract: Schizophrenia is a serious psychiatric disorder that affects the social life of patients. Psychiatric disorders are caused by a complex combination of genetic (G) and environmental (E) factors. Polysialylation represents a unique posttranslational modification of… read more here.
Keywords: disc1 mutants; mouse; disc1; disc1 mutant ... See more keywords