Whole-genome CRISPR screening identifies N-glycosylation as a genetic and therapeutic vulnerability in CALR-mutant MPNs
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DOI: 10.1182/blood.2022015629
Abstract: Calreticulin (CALR) mutations are important disease-initiating drivers of myeloproliferative neoplasms (MPNs) and cause hyperproliferation by binding to the thrombopoietin (TPO) receptor and inducing cytokine independent signaling. Jutzi and colleagues report on a CRISPR knockout screen… read more here.
Keywords: calr; genome crispr; glycosylation; calr mutant ... See more keywords