Mutant NPM1: Nuclear export and the mechanism of leukemogenesis
Sign Up to like & getrecommendations! Published in 2023 at "American Journal of Hematology"
DOI: 10.1002/ajh.26862
Abstract: NPM1 -mutated acute myeloid leukemia (AML) represents the most frequent genetic subtype of AML, accounting for about 30% to 35% of newly diagnosed cases in adults. 1 Because of its distinctive clinico-pathological and molecular features,… read more here.
Keywords: mutant npm1; npm1 mutated; npm1 nuclear; nuclear export ... See more keywords
Mutant NPM1 Hijacks Transcriptional Hubs to Maintain Pathogenic Gene Programs in Acute Myeloid Leukemia
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DOI: 10.1158/2159-8290.cd-22-0424
Abstract: Mutant NPM1 in leukemia obtains neomorphic activity to hijack active HOXA/B and MEIS1 transcription on chromatin via the association of XPO1 and blocks the histone deacetylase activity associated with myeloid differentiation. read more here.
Keywords: transcriptional hubs; mutant npm1; leukemia; hijacks transcriptional ... See more keywords
Leukemogenic nucleophosmin mutation disrupts the transcription factor hub that regulates granulomonocytic fates
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DOI: 10.1172/jci97117
Abstract: Nucleophosmin (NPM1) is among the most frequently mutated genes in acute myeloid leukemia (AML). It is not known, however, how the resulting oncoprotein mutant NPM1 is leukemogenic. To reveal the cellular machinery in which NPM1… read more here.
Keywords: cebpa runx1; mutant npm1; transcription; transcription factor ... See more keywords