The PI3K/mTOR dual inhibitor NVP‐BEZ235 stimulates mutant p53 degradation to exert anti‐tumor effects on triple‐negative breast cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12806
Abstract: Nearly half of human cancers harbor p53 mutations, and mutant p53 (mutp53) promotes carcinogenesis, metastasis, tumor recurrence and chemoresistance. mutp53 is observed in 30% of breast carcinomas, including triple‐negative breast cancer (TNBC), and thus mutp53… read more here.
Keywords: degradation; bez235; tnbc; mutant p53 ... See more keywords
Mutant p53: a novel target for the treatment of patients with triple‐negative breast cancer?
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DOI: 10.1002/ijc.30425
Abstract: The identification and validation of a targeted therapy for patients with triple‐negative breast cancer (TNBC) is currently one of the most urgent needs in breast cancer therapeutics. One of the key reasons for the failure… read more here.
Keywords: breast cancer; mutant p53; cancer; p53 ... See more keywords
Novel ovarian cancer maintenance therapy targeted at mortalin and mutant p53
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DOI: 10.1002/ijc.32830
Abstract: Current ovarian cancer maintenance therapy is limited by toxicity and no proven impact on overall survival. To study a maintenance strategy targeted at missense mutant p53, we hypothesized that the release of mutant p53 from… read more here.
Keywords: mutant p53; ovarian cancer; cancer; p53 ... See more keywords
Thiostrepton degrades mutant p53 by eliciting an autophagic response in SW480 cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26601
Abstract: Mutations in p53 gene are one of the hallmarks of tumor development. Specific targeting of mutant p53 protein has a promising role in cancer therapeutics. Our preliminary observation showed destabilization of mutant p53 protein in… read more here.
Keywords: p53 protein; bag3; treatment; thiostrepton ... See more keywords
MicroRNAs as Key Effectors in the p53 Network.
Sign Up to like & getrecommendations! Published in 2017 at "International review of cell and molecular biology"
DOI: 10.1016/bs.ircmb.2017.04.003
Abstract: The guardian of the genome p53 is embedded in a fine-spun network of MicroRNAs. p53 is able to activate or repress directly the transcription of MicroRNAs that are participating in the tumor-suppressive mission of p53.… read more here.
Keywords: p53 able; network; mutant p53; network micrornas ... See more keywords
Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer.
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DOI: 10.1016/j.ccell.2020.05.010
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is driven by co-existing mutations in KRAS and TP53. However, how these mutations collaborate to promote this cancer is unknown. Here, we uncover sequence-specific changes in RNA splicing enforced by mutant… read more here.
Keywords: altered rna; splicing mutant; mutant p53; cancer ... See more keywords
Nicotine promotes WRL68 cells proliferation due to the mutant p53 gain-of-function by activating CDK6-p53-RS-PIN1-STAT1 signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.0c00119
Abstract: The liver is an important organ with many tasks, such as dealing with drugs, alcohol and other toxins to remove them from the body. Nicotine is the more abundant component in cigarette smoking, which is… read more here.
Keywords: wrl68 cells; stat1; cells proliferation; mutant p53 ... See more keywords
Colletofragarone A2 Inhibits Cancer Cell Growth In Vivo and Leads to the Degradation and Aggregation of Mutant p53.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.2c00202
Abstract: Mutant p53 not only loses its original tumor suppressor function but also acquires new abilities regarding oncogenic progression. Therefore, the strategy of targeting mutant p53 has attracted attention for cancer therapy. We isolated colletofragarone A2… read more here.
Keywords: colletofragarone; mutant p53; cell growth; growth vivo ... See more keywords
Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation
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DOI: 10.1038/ncomms14844
Abstract: TP53, a critical tumour suppressor gene, is mutated in over half of all cancers resulting in mutant-p53 protein accumulation and poor patient survival. Therapeutic strategies to target mutant-p53 cancers are urgently needed. We show that… read more here.
Keywords: p53 protein; system; mutant p53; glutathione axis ... See more keywords
The hot-spot p53R172H mutant promotes formation of giant spermatogonia triggered by DNA damage
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DOI: 10.1038/onc.2016.374
Abstract: Overexpression of mutant p53 is a common finding in most cancers but testicular tumours accumulate wild-type p53 (wtp53). In contrast to the accepted concept that p53 homozygous mutant mice do not accumulate mutant p53 in… read more here.
Keywords: dna damage; gsg; p53r172h; formation ... See more keywords
Mutant p53 oncogenic functions in cancer stem cells are regulated by WIP through YAP/TAZ
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DOI: 10.1038/onc.2016.518
Abstract: Wild-type p53 (wtp53) is described as a tumour suppressor gene; mutations in this gene occur in many human cancers and promote oncogenic capacity. Here, we establish that the oncogenic activity of mutant p53 (mtp53) is… read more here.
Keywords: cancer stem; mtp53; mutant p53; yap taz ... See more keywords