The PI3K/mTOR dual inhibitor NVP‐BEZ235 stimulates mutant p53 degradation to exert anti‐tumor effects on triple‐negative breast cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12806
Abstract: Nearly half of human cancers harbor p53 mutations, and mutant p53 (mutp53) promotes carcinogenesis, metastasis, tumor recurrence and chemoresistance. mutp53 is observed in 30% of breast carcinomas, including triple‐negative breast cancer (TNBC), and thus mutp53… read more here.
Keywords: degradation; bez235; tnbc; mutant p53 ... See more keywords
Mutant p53: a novel target for the treatment of patients with triple‐negative breast cancer?
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DOI: 10.1002/ijc.30425
Abstract: The identification and validation of a targeted therapy for patients with triple‐negative breast cancer (TNBC) is currently one of the most urgent needs in breast cancer therapeutics. One of the key reasons for the failure… read more here.
Keywords: breast cancer; mutant p53; cancer; p53 ... See more keywords
Novel ovarian cancer maintenance therapy targeted at mortalin and mutant p53
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DOI: 10.1002/ijc.32830
Abstract: Current ovarian cancer maintenance therapy is limited by toxicity and no proven impact on overall survival. To study a maintenance strategy targeted at missense mutant p53, we hypothesized that the release of mutant p53 from… read more here.
Keywords: mutant p53; ovarian cancer; cancer; p53 ... See more keywords
Thiostrepton degrades mutant p53 by eliciting an autophagic response in SW480 cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26601
Abstract: Mutations in p53 gene are one of the hallmarks of tumor development. Specific targeting of mutant p53 protein has a promising role in cancer therapeutics. Our preliminary observation showed destabilization of mutant p53 protein in… read more here.
Keywords: p53 protein; bag3; treatment; thiostrepton ... See more keywords
MicroRNAs as Key Effectors in the p53 Network.
Sign Up to like & getrecommendations! Published in 2017 at "International review of cell and molecular biology"
DOI: 10.1016/bs.ircmb.2017.04.003
Abstract: The guardian of the genome p53 is embedded in a fine-spun network of MicroRNAs. p53 is able to activate or repress directly the transcription of MicroRNAs that are participating in the tumor-suppressive mission of p53.… read more here.
Keywords: p53 able; network; mutant p53; network micrornas ... See more keywords
Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer cell"
DOI: 10.1016/j.ccell.2020.05.010
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is driven by co-existing mutations in KRAS and TP53. However, how these mutations collaborate to promote this cancer is unknown. Here, we uncover sequence-specific changes in RNA splicing enforced by mutant… read more here.
Keywords: altered rna; splicing mutant; mutant p53; cancer ... See more keywords
Nicotine promotes WRL68 cells proliferation due to the mutant p53 gain-of-function by activating CDK6-p53-RS-PIN1-STAT1 signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.0c00119
Abstract: The liver is an important organ with many tasks, such as dealing with drugs, alcohol and other toxins to remove them from the body. Nicotine is the more abundant component in cigarette smoking, which is… read more here.
Keywords: wrl68 cells; stat1; cells proliferation; mutant p53 ... See more keywords
Colletofragarone A2 Inhibits Cancer Cell Growth In Vivo and Leads to the Degradation and Aggregation of Mutant p53.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.2c00202
Abstract: Mutant p53 not only loses its original tumor suppressor function but also acquires new abilities regarding oncogenic progression. Therefore, the strategy of targeting mutant p53 has attracted attention for cancer therapy. We isolated colletofragarone A2… read more here.
Keywords: colletofragarone; mutant p53; cell growth; growth vivo ... See more keywords
Pyrazolone-Based Zn(II) Complexes Display Antitumor Effects in Mutant p53-Carrying Cancer Cells.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.4c01298
Abstract: The synthesis and characterization of nine Schiff bases of pyrazolone ligands HLn (n = 1-9) and the corresponding zinc(II) complexes 1-9 of composition [Zn(Ln)2] (n = 1-9) are reported. The molecular structures of complexes 2,… read more here.
Keywords: cancer; pyrazolone based; based complexes; complexes display ... See more keywords
Pestones A and B from a Fungus Pestalotiopsis sp. Bound to Mutant p53 and Changed Its Conformation.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.4c01440
Abstract: Oncogenic mutant p53 is one of the targets for cancer therapy, and the development of anticancer drugs that reactivate mutant p53 is a promising strategy. The extract of fungus Pestalotiopsis sp. changed mutant p53 to… read more here.
Keywords: p53r175h cells; saos p53r175h; p53; fungus pestalotiopsis ... See more keywords
Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation
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DOI: 10.1038/ncomms14844
Abstract: TP53, a critical tumour suppressor gene, is mutated in over half of all cancers resulting in mutant-p53 protein accumulation and poor patient survival. Therapeutic strategies to target mutant-p53 cancers are urgently needed. We show that… read more here.
Keywords: p53 protein; system; mutant p53; glutathione axis ... See more keywords