PTEN deficiency confers colorectal cancer cell resistance to dual inhibitors of FLT3 and aurora kinase A.
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DOI: 10.1016/j.canlet.2018.08.011
Abstract: PTEN is a tumor suppressor found mutated in many cancers. From a synthetic lethality drug screen with PTEN-isogenic colorectal cancer cells, we found that mutant-PTEN cells were resistant to dual inhibitors of FLT3 and aurora… read more here.
Keywords: colorectal cancer; drug; mutant pten; pten cells ... See more keywords