Ras and exosome signaling.
Sign Up to like & getrecommendations! Published in 2019 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2019.02.004
Abstract: Ras gene (HRAS, NRAS, and KRAS) has been observed to be mutated and hyper-activated in a significant proportion of cancers. However, mutant Ras remains a challenging therapeutic target. Similarly, inhibition of targets upstream and downstream… read more here.
Keywords: exosome signaling; mutant ras; biology; ras exosome ... See more keywords
Inhibition of mutant RAS-RAF interaction by mimicking structural and dynamic properties of phosphorylated RAS
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.04.24.489309
Abstract: Undruggability of RAS proteins has necessitated alternative strategies for the development of effective inhibitors. In this respect, phosphorylation has recently come into prominence as this reversible post-translational modification attenuates sensitivity of RAS towards RAF. As… read more here.
Keywords: inhibition mutant; ras raf; mutant; mutant ras ... See more keywords
PO-196 Vav1 and Mutant K-Ras synergize in pancreatic ductal adenocarcinoma development: lessons from mouse models
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.714
Abstract: Introduction The overall 5 year survival rate of Pancreatic Ductal Adenocarcinoma (PDAC) is less than 5% and has remained stubbornly unchanged long time ago, despite the efforts in preclinical and clinical science. PDAC, the main form… read more here.
Keywords: vav1; pdac; mutant ras; vav1 rasg12d ... See more keywords
Abstract B031: Inhibition of mutant RAS via myotubularin related protein 7-mimicking peptide
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.ras23-b031
Abstract: The coiled coil domain of Myotubularin Related Protein 7 (MTMR7) and a peptide of the same sequence (M7CC) have been shown to have an anti-cancer effect via direct interaction with PPARγ (Weidner et al. 2020).… read more here.
Keywords: related protein; myotubularin related; mutant ras; ras ... See more keywords
Abstract B033: Wild-type RAS signaling is an essential therapeutic target in RAS-mutated cancers
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.ras23-b033
Abstract: Single-agent targeting of RAS-mutated cancers using RAF/MEK/ERK or PI3K/AKT pathway inhibitors is ineffective; blocking one pathway relieves negative feedback control of RTK signaling and hyperactivates parallel effector pathways. While combined MEK and PI3K inhibition is… read more here.
Keywords: mutated cancers; ras signaling; signaling essential; mutant ras ... See more keywords
Abstract IA21: Immune rewiring of mutant Ras tumors: Mechanisms and translational implications
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.ras23-ia21
Abstract: Oncogenic mutations in KRas are found in more than 90% of pancreatic tumors. These mutations are acquired at an early stage of disease and, in experimental models, have been shown to be essential for tumor… read more here.
Keywords: ras tumors; mutant ras; rewiring mutant; mechanisms translational ... See more keywords
Does Mutated K-RAS Oncogene Attenuate the Effect of Sulindac in Colon Cancer Chemoprevention?
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Prevention Research"
DOI: 10.1158/1940-6207.capr-17-0230
Abstract: The NSAID sulindac has been successfully used alone or in combination with other agents to suppress colon tumorigenesis in patients with genetic predisposition and also showed its efficacy in prevention of sporadic colon adenomas. At… read more here.
Keywords: sulindac; colon; ras oncogene; mutant ras ... See more keywords
Co-targeting translation and proteasome rapidly kills colon cancer cells with mutant RAS/RAF via ER stress
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.14063
Abstract: Colorectal cancers with mutant RAS/RAF are therapy refractory. Deregulated mRNA translation has become an emerging target in cancer treatment. We recently reported that mTOR inhibitors induce apoptosis via ER stress and the extrinsic pathway upon… read more here.
Keywords: mutant ras; stress; translation; colon cancer ... See more keywords
Mutant K-Ras in Pancreatic Cancer: An Insight on the Role of Wild-Type N-Ras and K-Ras-Dependent Cell Cycle Regulation
Sign Up to like & getrecommendations! Published in 2023 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb45030164
Abstract: The development of K-Ras independence may explain the failure of targeted therapy for pancreatic cancer (PC). In this paper, active N as well as K-Ras was shown in all human cell lines tested. In a… read more here.
Keywords: cell; pancreatic cancer; mutant ras; type ras ... See more keywords
Kavalactone Kawain Impedes Urothelial Tumorigenesis in UPII-Mutant Ha-Ras Mice via Inhibition of mTOR Signaling and Alteration of Cancer Metabolism
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28041666
Abstract: UPII-mutant Ha-ras transgenic mice develop urothelial hyperplasia and low-grade papillary carcinoma, which mimics human non-muscle invasive bladder cancer (NMIBC). We investigated the effects and mechanisms of kawain, a main kavalactone in the kava plant, on… read more here.
Keywords: bladder; upii mutant; mutant ras; mice ... See more keywords
Chemoprevention of Urothelial Cell Carcinoma Tumorigenesis by Dietary Flavokawain A in UPII-Mutant Ha-ras Transgenic Mice
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14030496
Abstract: Non-muscle-invasive bladder cancer (NMIBC) has one of the highest recurrence rates among all solid cancers and the highest lifetime treatment cost per patient. Therefore, the development of chemoprevention strategies for reducing the occurrence and recurrence… read more here.
Keywords: upii mutant; mutant ras; fka; mice ... See more keywords