Mutations in the RNA Splicing Factor SF3B1 Promote Transformation through MYC Stabilization
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DOI: 10.1182/blood-2018-99-110328
Abstract: Mutations in the RNA splicing factor SF3B1 are recurrent in CLL and myeloid neoplasms but their functional role in promoting tumorigenesis remain poorly understood. While SF3B1 mutations have been identified as promoting use of aberrant… read more here.
Keywords: sf3b1; mutant cells; figure; mutant sf3b1 ... See more keywords
Coordinated Mis-Splicing of Multiple Mitochondrial Iron Metabolism Genes Causes Ring Sideroblast Formation in SF3B1-Mutant MDS
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DOI: 10.1182/blood-2020-140817
Abstract: Splicing is a fundamental process by which introns are removed from primary RNA transcripts. Alternative splicing is a major mechanism of gene regulation by which eukaryotic cells expand their transcriptional repertoire. By contrast, aberrant splicing… read more here.
Keywords: sf3b1; formation; sf3b1 mutant; mutant sf3b1 ... See more keywords