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Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome

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0 Published in 2017 at "Nature Communications"

DOI: 10.1038/ncomms14060

Abstract: Somatic mutations in spliceosome genes are detectable in ∼50% of patients with myelodysplastic syndromes (MDS). We hypothesize that cells harbouring spliceosome gene mutations have increased sensitivity to pharmacological perturbation of the spliceosome. We focus on… read more here.

Keywords: u2af1 expressing; mutant u2af1; expressing cells; u2af1 s34f ... See more keywords