Pre-existing immunity to influenza virus hemagglutinin stalk might drive selection for antibody-escape mutant viruses in a human challenge model
Sign Up to like & getrecommendations! Published in 2020 at "Nature Medicine"
DOI: 10.1038/s41591-020-0937-x
Abstract: The conserved region of influenza hemagglutinin (HA) stalk (or stem) has gained attention as a potent target for universal influenza vaccines 1 – 5 . Although the HA stalk region is relatively well conserved, the… read more here.
Keywords: escape; influenza; stalk; mutant viruses ... See more keywords
A model of COVID-19 pandemic with vaccines and mutant viruses
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DOI: 10.1371/journal.pone.0275851
Abstract: This paper proposes a compartment model (SVEIHRM model) based on a system of ordinary differential equations to simulate the pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).Emergence of mutant viruses gave rise to multiple… read more here.
Keywords: vaccination; mutant viruses; number; multiple vaccinations ... See more keywords
Isolation and Characterization of Human Monoclonal Antibodies That Recognize the Influenza A(H1N1)pdm09 Virus Hemagglutinin Receptor-Binding Site and Rarely Yield Escape Mutant Viruses
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2018.02660
Abstract: The influenza A virus rapidly mutates to escape from antibodies. Here, we isolated and characterized three human monoclonal antibodies (mAbs) that neutralize A(H1N1)pdm09 viruses. Generation of escape mutant viruses suggested that these antibodies recognized conserved… read more here.
Keywords: escape; human monoclonal; monoclonal antibodies; mutant viruses ... See more keywords