Advanced MR imaging and 18F-DOPA PET characteristics of H3K27M-mutant and wild-type pediatric diffuse midline gliomas
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-019-04333-4
Abstract: PurposeThe aim of this study was to investigate MRI-derived diffusion weighted imaging (DWI), 1H-MR spectroscopy (1H-MRS) and arterial spin labeling (ASL) perfusion imaging in comparison with 18F-dihydroxyphenylalanine (DOPA) PET with respect to diagnostic evaluation of… read more here.
Keywords: dmg; dopa pet; wild type; mutant wild ... See more keywords
Exploring Degradation of Mutant and Wild-Type Epidermal Growth Factor Receptors Induced by Proteolysis-Targeting Chimeras.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00345
Abstract: Several epidermal growth factor receptor (EGFR) proteolysis-targeting chimeras (PROTACs), including MS39 and MS154 developed by us, have been reported to effectively degrade the mutant but not the wild-type (WT) EGFR. However, the mechanism underlying the… read more here.
Keywords: epidermal growth; growth factor; mutant wild; egfr ... See more keywords
Genomic feature differences in APC-mutant and wild-type colorectal cancer patients.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e15609
Abstract: e15609Background: Adenomatous polyposis coli (APC) is a tumor suppressor gene whose inactivating mutation leads to inherited familial adenomatous polyposis and subsequently almost definitive early ... read more here.
Keywords: apc mutant; feature differences; genomic feature; wild type ... See more keywords