The occhiolino (occ) mutant Zebrafish, a model for development of the optical function in the biological lens
Sign Up to like & getrecommendations! Published in 2017 at "Developmental Dynamics"
DOI: 10.1002/dvdy.24511
Abstract: Background: Zebrafish visual function depends on quality optics. An F3 screen for developmental mutations in the Zebrafish nervous system was conducted in wild‐type (wt) AB Zebrafish exposed to 3 mM of N‐ethyl‐N‐nitrosourea (ENU). Results: Mutant… read more here.
Keywords: occhiolino occ; model; mutant zebrafish; function ... See more keywords
Generation of foxn1/Casper Mutant Zebrafish for Allograft and Xenograft of Normal and Malignant Cells
Sign Up to like & getrecommendations! Published in 2020 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2020.07.020
Abstract: Summary Cell transplantation into immunodeficient recipients is a widely used approach to study stem cell and cancer biology; however, studying cell states post transplantation in vivo is inconvenient in mammals. Here, we generated a foxn1/Casper… read more here.
Keywords: foxn1 casper; casper; casper mutant; mutant zebrafish ... See more keywords
Modeling hypercholesterolemia and vascular lipid accumulation in LDL receptor mutant zebrafish[S]
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Lipid Research"
DOI: 10.1194/jlr.d081521
Abstract: Elevated plasma LDL cholesterol is the dominant risk factor for the development of atherosclerosis and cardiovascular disease. Deficiency in the LDL receptor (LDLR) is a major cause of familial hypercholesterolemia in humans, and the LDLR… read more here.
Keywords: ldl receptor; accumulation; hypercholesterolemia; mutant zebrafish ... See more keywords
High Behavioral Variability Mediated by Altered Neuronal Excitability in auts2 Mutant Zebrafish
Sign Up to like & getrecommendations! Published in 2021 at "eNeuro"
DOI: 10.1523/eneuro.0493-20.2021
Abstract: Abstract Autism spectrum disorders (ASDs) are characterized by abnormal behavioral traits arising from neural circuit dysfunction. While a number of genes have been implicated in ASDs, in most cases, a clear understanding of how mutations… read more here.
Keywords: excitability; mutant zebrafish; escape; variability ... See more keywords
Hyperactivation of mTORC1 in a double hit mutant zebrafish model of tuberous sclerosis complex causes increased seizure susceptibility and neurodevelopmental abnormalities
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.952832
Abstract: Tuberous sclerosis complex (TSC) is a multisystem genetic disorder caused by pathogenic variants in TSC1 and TSC2 genes. TSC patients present with seizures and brain abnormalities such as tubers and subependymal giant cells astrocytoma (SEGA).… read more here.
Keywords: mutant zebrafish; hit; model; tsc2 ... See more keywords
Multiple Developmental Defects in sox11a Mutant Zebrafish with Features of Coffin-Siris Syndrome
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.47510
Abstract: A previous study suggested that human Coffin-Siris syndrome is related to the mutation of SOX11. Since the homozygous SOX11 mutant mice died soon after birth, no suitable model was available for the study of the… read more here.
Keywords: developmental defects; coffin siris; sox11am mutant; multiple developmental ... See more keywords