Abstract 4078: Tumors with class 3 BRAF mutants are sensitive to the inhibition of activated RAS
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DOI: 10.1158/1538-7445.am2017-4078
Abstract: Approximately two hundred mutant BRAF alleles have been identified in human tumors. Physiologic activation of RAF isoforms requires RAS-dependent induction of their dimerization. Activating BRAF mutants cause ERK dependent feedback inhibition of RAS.GTP and are… read more here.
Keywords: braf mutants; class braf; mutants sensitive; braf ... See more keywords