Structural analysis of EhPSP in complex with 3-phosphoglyceric acid from Entamoeba histolytica reveals a basis for its lack of phosphoglycerate mutase activity.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.02.153
Abstract: Entamoeba histolytica phosphoserine phosphatase (EhPSP), a regulatory enzyme in the serine biosynthetic pathway, is also a structural homolog of cofactor-dependent phosphoglycerate mutase (dPGM). However, despite sharing many of its catalytic residues with dPGM, EhPSP displays… read more here.
Keywords: ehpsp; ehpsp complex; phosphoglycerate mutase; entamoeba histolytica ... See more keywords
Structural Basis of the Molecular Switch between Phosphatase and Mutase Functions of Human Phosphomannomutase 1 under Ischemic Conditions.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b00223
Abstract: The human phosphomannomutases PMM1 and PMM2 catalyze the interconversion of hexose 6-phosphates and hexose 1-phosphates. The two isoforms share 66% sequence identity and have kinetic properties similar to those of mutases in vitro but differ… read more here.
Keywords: structural basis; pmm1; phosphatase; phosphatase mutase ... See more keywords
Structure of metallochaperone in complex with the cobalamin-binding domain of its target mutase provides insight into cofactor delivery
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2214085120
Abstract: Significance Guanosine triphosphate hydrolyase (GTPase) metallochaperones enable the delivery of metal cofactors to client proteins in host organisms that range from the pathogen Helicobacter pylori to humans. The combination of metal with protein facilitates critical… read more here.
Keywords: mutase; complex cobalamin; structure metallochaperone; delivery ... See more keywords
Sumoylation-deficient phosphoglycerate mutase 2 impairs myogenic differentiation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.1052363
Abstract: Phosphoglycerate mutase 2 (PGAM2) is a critical glycolytic enzyme that is highly expressed in skeletal muscle. In humans, naturally occurring mutations in Phosphoglycerate mutase 2 have been etiologically linked to glycogen storage disease X (GSDX).… read more here.
Keywords: mutase; sumoylation; differentiation; c2c12 cells ... See more keywords