Central nervous system relapse after allogeneic HCT in FLT3-mutated AML
Sign Up to like & getrecommendations! Published in 2024 at "Annals of Hematology"
DOI: 10.1007/s00277-024-06106-y
Abstract: Central nervous system (CNS) relapse in acute myeloid leukemia (AML) is rare, but prognostically extremely unfavorable and associated with very high mortality rates. Aim of our single-center study was to define risk factors for CNS… read more here.
Keywords: relapse; central nervous; mutated aml; hct ... See more keywords
Diagnostic and therapeutic pitfalls in NPM1-mutated AML: notes from the field
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DOI: 10.1038/s41375-021-01222-4
Abstract: Mutations of Nucleophosmin (NPM1) are the most common genetic abnormalities in adult acute myeloid leukaemia (AML), accounting for about 30% of cases. NPM1-mutated AML has been recognized as distinct entity in the 2017 World Health… read more here.
Keywords: diagnostic therapeutic; mutated aml; therapeutic pitfalls; cases npm1 ... See more keywords
Biological and therapeutic implications of a unique subtype of NPM1 mutated AML
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DOI: 10.1038/s41467-021-21233-0
Abstract: In acute myeloid leukemia (AML), molecular heterogeneity across patients constitutes a major challenge for prognosis and therapy. AML with NPM1 mutation is a distinct genetic entity in the revised World Health Organization classification. However, differing… read more here.
Keywords: biological therapeutic; therapeutic implications; mutated aml; drug ... See more keywords
Revisiting the prognostic role of FLT3 mutations in acute myelogenous leukemia
Sign Up to like & getrecommendations! Published in 2023 at "Expert Review of Hematology"
DOI: 10.1080/17474086.2023.2202849
Abstract: ABSTRACT Introduction Approximately one-third of patients with acute myelogenous leukemia (AML) harbor mutations in the fms-like tyrosine kinase 3 (FLT3) gene. The features regarding prognostic impact of FLT3 mutated AML have been widely investigated and… read more here.
Keywords: flt3; myelogenous leukemia; mutated aml; acute myelogenous ... See more keywords
ET occurring in NPM1‐mutated AML during molecular complete remission: A further potential evolution of a complex disease
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DOI: 10.1111/bjh.70076
Abstract: Nucleophosmin 1 (NPM1)mut acute myeloid leukaemia (AML) patients may experience different disease evolutions after achieving complete remission. Essential thrombocythaemia (ET) may arise in ≈3% of NPM1mutAML patients achieving molecular remission after treatment. The presence of… read more here.
Keywords: disease; mutated aml; complete remission; npm1 mutated ... See more keywords
Post‐Relapse Outcomes of Older Patients With NPM1‐Mutated AML Are Favorable With Allo Transplant in Second Remission
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Haematology"
DOI: 10.1111/ejh.14375
Abstract: Molecular assessment of measurable residual disease (MRD) in NPM1‐mutated AML patients is a powerful prognostic tool to identify the risk of relapse. There is limited data regarding MRD‐guided decisions against alloSCT in elderly patients and… read more here.
Keywords: flt3 itd; relapse; mutated aml; npm1 mutated ... See more keywords
Allogeneic transplant for FLT3-ITD mutated AML: a focus on FLT3 inhibitors before, during, and after transplant
Sign Up to like & getrecommendations! Published in 2019 at "Therapeutic Advances in Hematology"
DOI: 10.1177/2040620719882666
Abstract: FMS-like tyrosine kinase 3 (FLT3) mutations are one of the most frequently encountered genetic alterations in acute myeloid leukemia (AML), and are generally associated with unfavorable outcomes. Several tools are currently available to provide an… read more here.
Keywords: transplant flt3; allogeneic transplant; flt3; mutated aml ... See more keywords
Synergistic Effect of Trifluridine and PARPi Combination in Targeting TP53-Mutated AML
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DOI: 10.1182/blood-2024-201781
Abstract: Introduction: TP53 encodes the tumor suppressor p53 protein, which is critical in regulating response to DNA damage, and is one of the most commonly mutated genes in human cancer. In acute myeloid leukemia (AML) TP53… read more here.
Keywords: tp53 mutated; mutated aml; combination; cell ... See more keywords
Inhibition of Threonine Tyrosine Kinase Suppressed TP53-mutated Acute Myeloid Leukaemia Via Synergism with Venetoclax and Activation of the Cgas-Sting Pathway
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DOI: 10.1182/blood-2024-201920
Abstract: Background. Acute myeloid leukaemia (AML) carrying TP53 mutation portends an extremely poor prognosis. Intensive chemotherapy and allogeneic haematopoietic stem cell transplantation are largely ineffective and the 5-year overall survival was less than 10%. There is… read more here.
Keywords: cfi 402257; tp53 mutated; mutated aml; activation ... See more keywords
Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A, NPM1, and FLT3-ITD triple-mutated AML.
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood.2018862383
Abstract: FLT3, DNMT3A, and NPM1 are the most frequently mutated genes in cytogenetically normal acute myeloid leukemia (AML), but little is known about how these mutations synergize upon co-occurrence. Here we show that triple-mutated AML is… read more here.
Keywords: cell; triple mutated; dnmt3a npm1; mutated aml ... See more keywords
How I diagnose and treat NPM1-mutated AML.
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood.2020008211
Abstract: Mutations of the nucleophosmin (NPM1) gene, encoding for a nucleolar multifunctional protein, occur in about one-third of adult acute myeloid leukemia (AML). NPM1-mutated AML exhibits unique molecular, pathological and clinical features, that led to its… read more here.
Keywords: diagnosis; diagnose treat; mutated aml; npm1 mutated ... See more keywords