Diagnostic and therapeutic pitfalls in NPM1-mutated AML: notes from the field
Sign Up to like & getrecommendations! Published in 2021 at "Leukemia"
DOI: 10.1038/s41375-021-01222-4
Abstract: Mutations of Nucleophosmin (NPM1) are the most common genetic abnormalities in adult acute myeloid leukaemia (AML), accounting for about 30% of cases. NPM1-mutated AML has been recognized as distinct entity in the 2017 World Health… read more here.
Keywords: diagnostic therapeutic; mutated aml; therapeutic pitfalls; cases npm1 ... See more keywords
Biological and therapeutic implications of a unique subtype of NPM1 mutated AML
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-21233-0
Abstract: In acute myeloid leukemia (AML), molecular heterogeneity across patients constitutes a major challenge for prognosis and therapy. AML with NPM1 mutation is a distinct genetic entity in the revised World Health Organization classification. However, differing… read more here.
Keywords: biological therapeutic; therapeutic implications; mutated aml; drug ... See more keywords
Revisiting the prognostic role of FLT3 mutations in acute myelogenous leukemia
Sign Up to like & getrecommendations! Published in 2023 at "Expert Review of Hematology"
DOI: 10.1080/17474086.2023.2202849
Abstract: ABSTRACT Introduction Approximately one-third of patients with acute myelogenous leukemia (AML) harbor mutations in the fms-like tyrosine kinase 3 (FLT3) gene. The features regarding prognostic impact of FLT3 mutated AML have been widely investigated and… read more here.
Keywords: flt3; myelogenous leukemia; mutated aml; acute myelogenous ... See more keywords
Allogeneic transplant for FLT3-ITD mutated AML: a focus on FLT3 inhibitors before, during, and after transplant
Sign Up to like & getrecommendations! Published in 2019 at "Therapeutic Advances in Hematology"
DOI: 10.1177/2040620719882666
Abstract: FMS-like tyrosine kinase 3 (FLT3) mutations are one of the most frequently encountered genetic alterations in acute myeloid leukemia (AML), and are generally associated with unfavorable outcomes. Several tools are currently available to provide an… read more here.
Keywords: transplant flt3; allogeneic transplant; flt3; mutated aml ... See more keywords
Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A, NPM1, and FLT3-ITD triple-mutated AML.
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood.2018862383
Abstract: FLT3, DNMT3A, and NPM1 are the most frequently mutated genes in cytogenetically normal acute myeloid leukemia (AML), but little is known about how these mutations synergize upon co-occurrence. Here we show that triple-mutated AML is… read more here.
Keywords: cell; triple mutated; dnmt3a npm1; mutated aml ... See more keywords
How I diagnose and treat NPM1-mutated AML.
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood.2020008211
Abstract: Mutations of the nucleophosmin (NPM1) gene, encoding for a nucleolar multifunctional protein, occur in about one-third of adult acute myeloid leukemia (AML). NPM1-mutated AML exhibits unique molecular, pathological and clinical features, that led to its… read more here.
Keywords: diagnosis; diagnose treat; mutated aml; npm1 mutated ... See more keywords
Pevonedistat with azacitidine in older patients with TP53-mutated AML: a phase 2 study with laboratory correlates
Sign Up to like & getrecommendations! Published in 2022 at "Blood Advances"
DOI: 10.1182/bloodadvances.2022008625
Abstract: Finding safe and effective treatment strategies for patients with TP53 -mutated acute myeloid leukemia (AML) remains an important unmet need. read more here.
Keywords: mutated aml; older patients; patients tp53; pevonedistat azacitidine ... See more keywords
Targeted therapy in NPM1-mutated AML: Knowns and unknowns
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.972606
Abstract: Acute myeloid leukemia (AML) is a heterogeneous disease characterized by malignant proliferation of myeloid hematopoietic stem/progenitor cells. NPM1 represents the most frequently mutated gene in AML and approximately 30% of AML cases carry NPM1 mutations.… read more here.
Keywords: therapy npm1; targeted therapy; npm1 mutated; mutated aml ... See more keywords
High Incidence of Invasive Fungal Diseases in Patients with FLT3-Mutated AML Treated with Midostaurin: Results of a Multicenter Observational SEIFEM Study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Fungi"
DOI: 10.3390/jof8060583
Abstract: The potential drug-drug interactions of midostaurin may impact the choice of antifungal (AF) prophylaxis in FLT3-positive acute myeloid leukemia (AML) patients. To evaluate the incidence of invasive fungal diseases (IFD) during the treatment of FLT3-mutated… read more here.
Keywords: mutated aml; incidence; flt3 mutated; incidence invasive ... See more keywords
Up-regulation of EMT-related gene VCAN by NPM1 mutant-driven TGF-β/cPML signalling promotes leukemia cell invasion
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cancer"
DOI: 10.7150/jca.30223
Abstract: Acute myeloid leukemia (AML) with mutated nucleophosmin (NPM1) is acknowledged as a distinct leukemia entity in the 2016 updated World Health Organization (WHO) classification. NPM1-mutated AML patients are correlated with higher extramedullary involvement. Epithelial-mesenchymal transition… read more here.
Keywords: emt related; related gene; invasion; mutated aml ... See more keywords