Direct evidence for the age-dependent demise of GNAS-mutated cells in oral fibrous dysplasia.
Sign Up to like & getrecommendations! Published in 2018 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2018.05.018
Abstract: OBJECTIVE Fibrous dysplasia (FD) is a benign bone disease characterized by fibro-osseous lesions. FD is caused by somatic mutations in the gene, guanine nucleotide-binding protein, alpha stimulating activity polypeptide 1 (GNAS), which encodes the G… read more here.
Keywords: age dependent; evidence age; mutated cells; fibrous dysplasia ... See more keywords
High-throughput drug screening identifies the ATR-CHK1 pathway as a therapeutic vulnerability of CALR mutated hematopoietic cells
Sign Up to like & getrecommendations! Published in 2021 at "Blood Cancer Journal"
DOI: 10.1038/s41408-021-00531-2
Abstract: Mutations of calreticulin (CALR) are the second most prevalent driver mutations in essential thrombocythemia and primary myelofibrosis. To identify potential targeted therapies for CALR mutated myeloproliferative neoplasms, we searched for small molecules that selectively inhibit… read more here.
Keywords: atr chk1; calr mutated; mutated cells; calr ... See more keywords
Targeting IDH1-Mutated Malignancies with NRF2 Blockade.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the National Cancer Institute"
DOI: 10.1093/jnci/djy230
Abstract: Background Neomorphic IDH1 mutations disrupt the redox balance by promoting reactive oxygen species (ROS) production. However, the mechanism by which IDH1-mutant cells maintain ROS homeostasis remains elusive. It is also not known whether reprogrammed ROS… read more here.
Keywords: nrf2 blockade; mutated cells; idh1 mutated; idh1 ... See more keywords