Mutated clones are the new normal
Sign Up to like & getrecommendations! Published in 2019 at "Science"
DOI: 10.1126/science.aax5525
Abstract: Measuring and understanding the dynamics of clonal cell populations is key for cancer prevention Cancers are formed by the expansion of harmful “mutational clones,” which are cell populations carrying the same DNA mutations. How harmful… read more here.
Keywords: cell populations; pathology; new normal; cancer ... See more keywords
Pediatric B cell repertoires are enriched for naive clonal phenotypes and are shaped by distinct selection dynamics
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2025.1618234
Abstract: B cell development in early life sets the stage for how the adaptive immune system will function. Although little is known about B cell biology in children, especially from tissue-residing B cells, it has been… read more here.
Keywords: repertoires enriched; cell repertoires; mutated clones; cell ... See more keywords