Prognostic utility of six mutated genes for older patients with acute myeloid leukemia
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DOI: 10.1002/ijc.31178
Abstract: Approximately 50% of older patients with acute myeloid leukemia (AML) do not obtain chromosomal abnormalities as an effective risk‐stratification, and present cytogenetically normal AML (CN‐AML). To develop a reliable prediction model for stratifying the risk… read more here.
Keywords: mutated genes; patients acute; myeloid leukemia; acute myeloid ... See more keywords
Integrative analysis of mutated genes and mutational processes reveals novel mutational biomarkers in colorectal cancer
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DOI: 10.1186/s12859-022-04652-8
Abstract: Background Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. Recent studies have observed causative mutations in susceptible genes related to colorectal cancer in 10 to 15% of the patients. This… read more here.
Keywords: mutated genes; cancer; integrative analysis; analysis mutated ... See more keywords
The long tail of significantly mutated genes in prostate cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.6_suppl.131
Abstract: 131Background: The mutational landscapes of primary and metastatic PCa have been robustly analyzed in multiple whole exome sequencing (WES) studies. We hypothesized that an aggregate, uniform analysis of all data generated to date would enable… read more here.
Keywords: mutated genes; genes pathways; significantly mutated; primary metastatic ... See more keywords
Gene Mutational Clusters in the Tumors of Colorectal Cancer Patients With a Family History of Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.814397
Abstract: Introduction Family history is a high-risk factor for colorectal cancer (CRC). The risk comes not only from known germline mutations but also from the other family-related mechanisms. Uncovering them would be an important step to… read more here.
Keywords: family; colorectal cancer; mutated genes; family history ... See more keywords
Evolutionary Analysis of TCGA Data Using Over- and Under- Mutated Genes Identify Key Molecular Pathways and Cellular Functions in Lung Cancer Subtypes
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DOI: 10.3390/cancers15010018
Abstract: Simple Summary Evolution drives the initiation and progression of cancer. This is apparent in the concept of “driver mutations” that initiate cancer and observed in cells of the lineage. Less appreciated is natural selection’s role… read more here.
Keywords: driver; conserved genes; subtype specific; mutated genes ... See more keywords
Review of Recurrently Mutated Genes in Craniosynostosis Supports Expansion of Diagnostic Gene Panels
Sign Up to like & getrecommendations! Published in 2023 at "Genes"
DOI: 10.3390/genes14030615
Abstract: Craniosynostosis, the premature fusion of the cranial sutures, affects ~1 in 2000 children. Although many patients with a genetically determined cause harbor a variant in one of just seven genes or have a chromosomal abnormality,… read more here.
Keywords: recurrently mutated; craniosynostosis; gene panels; review recurrently ... See more keywords