Histologic transformation of epidermal growth factor receptor-mutated lung cancer.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of cancer"
DOI: 10.1016/j.ejca.2022.02.006
Abstract: PURPOSE This study aimed to determine the incidence and clinical course of epidermal growth factor receptor (EGFR)-mutated lung cancer with histologic transformation (HT). PATIENTS AND METHODS We conducted a multicentre, retrospective, cohort study of patients… read more here.
Keywords: cancer; epidermal growth; transformation; lung cancer ... See more keywords
Next‐generation sequencing assisted diagnosis of cervical metastasis in EGFR‐mutated lung adenocarcinoma: A case report
Sign Up to like & getrecommendations! Published in 2021 at "Thoracic Cancer"
DOI: 10.1111/1759-7714.14143
Abstract: EGFR mutation has been detected in more than half of non‐small cell lung cancer (NSCLC) patients in Asia. Lung cancer is the main cause of malignant tumor‐related death worldwide. Although distant metastases often occurs in… read more here.
Keywords: lung adenocarcinoma; egfr mutated; mutated lung; cervical metastasis ... See more keywords
Abstract C045: Exploring EGLN1/PHD2 role in KRAS mutated lung cancer: insights into mitochondrial modulation and therapeutic opportunities
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-25-c045
Abstract: Lung cancer is the first cause of cancer-related death. In lung adenocarcinoma (LUAD), different genetic alterations can be targeted with small-molecule compounds, including the KRAS inhibitors. However, the development of resistance mechanisms indicates that exploring… read more here.
Keywords: cancer; kras mutated; role; lung cancer ... See more keywords
Treating Choroidal Metastases and Improving Vision with Osimertinib in EGFR T790M-Mutated Lung Adenocarcinoma: A Case Report and Review of the Literature
Sign Up to like & getrecommendations! Published in 2020 at "Ocular Oncology and Pathology"
DOI: 10.1159/000510602
Abstract: A 41-year-old never-smoking female was diagnosed with epidermal growth factor receptor (EGFR)-mutated T2bN3M1b lung adenocarcinoma with axillary lymph nodes. She complained of blurred vision in the left eye (2/60) and was subsequently found to have… read more here.
Keywords: lung adenocarcinoma; mutated lung; treatment; vision ... See more keywords
An integrative functional genomics approach reveals EGLN1 as a novel therapeutic target in KRAS mutated lung adenocarcinoma
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DOI: 10.1186/s12943-021-01357-z
Abstract: Main text Despite extensive research and the recent introduction of innovative therapeutics, lung cancer remains the first cause of cancer-related death, with a 5 year survival of only 17% [1]. In lung adenocarcinoma (AD), the… read more here.
Keywords: lung adenocarcinoma; kras mutated; mutated lung; integrative functional ... See more keywords
Co-mutations in surgically resected and EGFR mutated lung adenocarcinoma: A subset analysis of the large prospective cohort study.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e20520
Abstract: e20520Background: Several studies including LUX LUNG 3 and 6 have shown that there are biological differences between EGFR exon 19 deletions (del19) and exon 21 L858R mutation (L858R) in lung adeno... read more here.
Keywords: surgically resected; egfr mutated; mutated lung; mutations surgically ... See more keywords
Adjuvant therapies in stages I–III epidermal growth factor receptor-mutated lung cancer: current and future perspectives
Sign Up to like & getrecommendations! Published in 2023 at "Translational Lung Cancer Research"
DOI: 10.21037/tlcr-22-723
Abstract: Surgical resection followed by adjuvant cisplatin-based chemotherapy is the recommended treatment for patients with completely resected stage IB–IIIA non-small cell lung cancer (NSCLC). Even with the best management, recurrence is common and increases with disease… read more here.
Keywords: lung cancer; mutated lung; epidermal growth; stage ... See more keywords
High PD-L1 Expression is Associated with Unfavorable Clinical Outcome in EGFR-Mutated Lung Adenocarcinomas Treated with Targeted Therapy
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DOI: 10.2147/ott.s271011
Abstract: Purpose Although programmed death-ligand 1 (PD-L1) expression is widely accepted as a predictive and prognostic biomarker in immunotherapy, its implications in lung cancer patients with driving mutations are still unclear. The objective of this study… read more here.
Keywords: expression; mutated lung; outcome; high expression ... See more keywords
Validation of Immunohistochemistry for the Detection of BRAF V600E-Mutated Lung Adenocarcinomas
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DOI: 10.3390/cancers11060866
Abstract: BRAF V600E mutation, a missense mutation in exon 15 resulting in valine substitution for glutamate at position 600 within the kinase domain of BRAF oncogene, is found in a subset of lung adenocarcinoma (ADC). The… read more here.
Keywords: braf v600e; v600e mutated; v600e; mutated lung ... See more keywords
Systemic Inflammation Index and Tumor Glycolytic Heterogeneity Help Risk Stratify Patients with Advanced Epidermal Growth Factor Receptor-Mutated Lung Adenocarcinoma Treated with Tyrosine Kinase Inhibitor Therapy
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DOI: 10.3390/cancers14020309
Abstract: Simple Summary Patients with advanced epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma have been known to respond to first-line tyrosine kinase inhibitor (TKI) treatment. However, a subgroup of patients are non-responsive to the treatment, with… read more here.
Keywords: inflammation; lung adenocarcinoma; patients advanced; mutated lung ... See more keywords
Characterizing the Clinical and Molecular Profile of SETD2-Mutated Lung Adenocarcinoma
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DOI: 10.3390/cancers17213540
Abstract: Simple Summary SETD2 is an understudied gene that encodes for a histone methyltransferase implicated in lung cancer tumorigenesis. The goal of this study is to elucidate the characteristics and prognosis of SETD2-mutated lung adenocarcinoma. With… read more here.
Keywords: lung; lung adenocarcinoma; setd2 mutated; setd2 ... See more keywords