PDE4D promotes FAK-mediated cell invasion in BRAF-mutated melanoma
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DOI: 10.1038/onc.2016.469
Abstract: The cyclic AMP (cAMP) signaling pathway is critical in melanocyte biology for regulating differentiation. It is downregulated by phosphodiesterase (PDE) enzymes, which degrade cAMP itself. In melanoma evidence suggests that inhibition of the cAMP pathway… read more here.
Keywords: invasion; braf mutated; cell invasion; pde4d ... See more keywords
PLA1A expression as a diagnostic marker of BRAF-mutant metastasis in melanoma cancer
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DOI: 10.1038/s41598-021-85595-7
Abstract: BRAF and NRAS are the most reported mutations associated to melanomagenesis. The lack of accurate diagnostic markers in response to therapeutic treatment in BRAF/NRAS-driven melanomagenesis is one of the main challenges in melanoma personalized therapy.… read more here.
Keywords: melanoma; diagnostic marker; braf; pla1a ... See more keywords
Clinical and radiological response of BRAF inhibition and MEK inhibition in patients with brain metastases from BRAF-mutated melanoma
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DOI: 10.1097/cmr.0000000000000429
Abstract: Patients with brain metastases (BM) from melanoma have an overall survival (OS) of 2–6 months after whole-brain radiotherapy. Targeted therapy (TT) is an effective treatment for BRAF-mutated metastatic melanoma. Moreover, recent studies indicate intracranial responses… read more here.
Keywords: patients brain; braf mutated; inhibition; mutated melanoma ... See more keywords
Complete response of brainstem metastasis in BRAF-mutated melanoma without stereotactic radiosurgery after initiation of encorafenib and binimetinib
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DOI: 10.1097/cmr.0000000000000750
Abstract: Metastatic melanoma is often accompanied by the development of brain metastases, at presentation or during the course of therapy. Local therapies such as surgery and radiation have been considered standard treatments for intracranial disease. However,… read more here.
Keywords: complete response; braf mutated; melanoma; mutated melanoma ... See more keywords
Targeted treatment of advanced NRAS-mutated melanoma
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DOI: 10.18632/oncotarget.21388
Abstract: NRAS-mutations most commonly in codon 61 (Q61R or Q61K) can be detected in around 20% of cutaneous melanomas and have been found more frequently in nodular primary melanomas and primary tumors from skin sites with… read more here.
Keywords: melanoma; inhibitor; nras mutated; trial ... See more keywords