Insight into the key features for ligand binding in Y1230 mutated c-Met kinase domain by molecular dynamics simulations
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DOI: 10.1080/07391102.2017.1340852
Abstract: c-Met kinase has been considered as an attractive target for developing antitumor agents. The strong interactions between Tyr1230 and the inhibitors emphasized its importance for ligand binding. The clinically related Tyr1230 mutations have made negative… read more here.
Keywords: kinase; kinase domain; ligand binding; met kinase ... See more keywords