SYK is activated by mutated MYD88 and drives pro-survival signaling in MYD88 driven B-cell lymphomas
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DOI: 10.1038/s41408-020-0277-6
Abstract: Activating MYD88 mutations promote pro-survival signaling through BTK and HCK, both targets of ibrutinib. Despite high response rates, complete responses to ibrutinib are lacking, and other MYD88 triggered pro-survival pathways may contribute to primary drug… read more here.
Keywords: pro survival; mutated myd88; syk; myd88 mutated ... See more keywords