Retrospective efficacy analysis of immune checkpoint inhibitors in patients with EGFR‐mutated non‐small cell lung cancer
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.2037
Abstract: Treatment with epidermal growth factor receptor (EGFR)‐tyrosine kinase inhibitors (TKIs) leads to initial response in most patients with EGFR‐mutated non‐small cell lung cancer (NSCLC). In contrast, little is known of the subpopulation of patients with… read more here.
Keywords: egfr mutated; mutated non; non small; cancer ... See more keywords
Efficacy and safety of first‐line treatments for patients with advanced anaplastic lymphoma kinase mutated, non–small cell cancer: A systematic review and network meta‐analysis
Sign Up to like & getrecommendations! Published in 2023 at "Cancer"
DOI: 10.1002/cncr.34664
Abstract: This study compares the safety and efficacy of first‐line treatments for anaplastic lymphoma kinase (ALK)‐mutated non–small cell lung cancer (NSCLC). read more here.
Keywords: lymphoma kinase; anaplastic lymphoma; first line; mutated non ... See more keywords
Overall Survival Analysis and Characterization of an EGFR Mutated Non-Small Cell Lung Cancer (NSCLC) Population.
Sign Up to like & getrecommendations! Published in 2018 at "Archivos de bronconeumologia"
DOI: 10.1016/j.arbres.2017.07.012
Abstract: BACKGROUND Patients with activating somatic mutations in the Epidermal Growth Factor Receptor (EGFR) have better clinical outcomes when treated with Tyrosine Kinase Inhibitors (TKI) over chemotherapy. However, the impact of the use of TKIs on… read more here.
Keywords: analysis; mutated non; lung cancer; overall survival ... See more keywords
Initial Patient Characteristics Associated With Ineligibility for Second‐Line Therapy After Progression on First‐Line Osimertinib in EGFR ‐Mutated Non‐Small Cell Lung Cancer
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DOI: 10.1111/1759-7714.70192
Abstract: Osimertinib, an irreversible third‐generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR‐TKI), improves survival in patients with EGFR‐mutated non‐small‐cell lung cancer (NSCLC). However, a substantial proportion of patients do not proceed to subsequent therapy (ST).… read more here.
Keywords: cancer; non small; mutated non; therapy ... See more keywords
Abstract A142: Targeting FGFR to overcome EMT-related resistance in EGFR-mutated non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-17-a142
Abstract: Epithelial-to-mesenchymal transition (EMT) has been identified as a mechanism of both adaptive and acquired resistance to EGFR tyrosine kinase inhibitors (TKIs) in in vitro models and clinical samples of EGFR-mutated non-small cell lung cancer (NSCLC).… read more here.
Keywords: egfr mutated; egfr; resistance egfr; resistance ... See more keywords
Early-stage KRAS G12C-mutated non-small cell lung cancer (NSCLC) in Australia.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.e21053
Abstract: e21053Background: KRAS is frequently mutated in NSCLC, especially in Caucasian populations. Until recently there have not been effective targeted therapies against KRAS but the recent advent of act... read more here.
Keywords: non small; g12c mutated; stage kras; mutated non ... See more keywords
Efficacy of adjuvant EGFR inhibitors and impact of clinical factors in resected EGFR-mutated non-small-cell lung cancer: a meta-analysis.
Sign Up to like & getrecommendations! Published in 2022 at "Future oncology"
DOI: 10.2217/fon-2021-0934
Abstract: Background: The role of adjuvant EGFR tyrosine kinase inhibitors (TKIs) in resected EGFR-mutated non-small-cell lung cancer (NSCLC) remains unclear. Materials & methods: We evaluated pooled hazard ratio and 95% CI for disease-free survival, overall survival and… read more here.
Keywords: non small; survival; resected egfr; adjuvant egfr ... See more keywords
Current Status of Multimodal Therapy for Oligometastatic Disease, Induced Oligometastatic Disease, and Oligo-Progressive Disease in EGFR-Mutated Non-Small-Cell Lung Cancer
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DOI: 10.3390/cancers17132202
Abstract: Simple Summary The treatment landscape for EGFR-mutated non-small-cell lung cancer (NSCLC) has significantly evolved with the introduction of EGFR tyrosine kinase inhibitors (EGFR-TKIs). However, acquired resistance to EGFR-TKIs remains inevitable, limiting long-term survival. Recent evidence… read more here.
Keywords: disease; therapy; mutated non; egfr mutated ... See more keywords
The Landscape and Management of Brain Parenchymal and Leptomeningeal Metastases in EGFR Mutated Non-Small Cell Lung Cancer
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DOI: 10.3390/cancers17152434
Abstract: Simple Summary Spread of lung cancer to the brain and lining of the central nervous system is a devastating consequent of disease and is especially common with EGFR mutations. Here, we explore the existing literature… read more here.
Keywords: non small; mutated non; lung; lung cancer ... See more keywords
Recurrent EGFR-Mutated Non-Small Cell Lung Cancer Discovered by Abnormal Mammogram: Adjuvant/Frontline Metastatic Management Options.
Sign Up to like & getrecommendations! Published in 2020 at "Oncology"
DOI: 10.46883/onc.2020.3409.0347
Abstract: Breast metastasis from extramammary malignancy is rare, with a reported incidence rate of 0.4% to 1.3% in the published literature. The primary malignancies that most commonly metastasize to the breast are leukemia, lymphoma, and malignant… read more here.
Keywords: small cell; egfr mutated; mutated non; lung cancer ... See more keywords
Miliary EGFR mutated non‐small cell lung cancer
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DOI: 10.5694/mja2.50901
Abstract: A 58-year-old man presented with shortness of breath on exertion and cough. The patient was previously very fit with excellent exercise tolerance. He had a light, distant smoking history and travelled to Japan, Hong Kong… read more here.
Keywords: egfr mutated; cell lung; mutated non; non small ... See more keywords