Elevated expression of the EZH2 gene in CALR-mutated patients with primary myelofibrosis
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Hematology"
DOI: 10.1007/s00277-018-3287-8
Abstract: Primary myelofibrosis (PMF) is one of the BCR/ABL-negative myeloproliferative neoplasms (MPNs), characterized by the diffuse fibrous hyperproliferation, bone marrow osteosclerosis, extramedullary hematopoiesis, and marked splenomegaly. The patients with PMF have an insidious onset, a long… read more here.
Keywords: mutated patients; primary myelofibrosis; calr mutated; expression ezh2 ... See more keywords
Are ovarian response and pregnancy rates similar in selected FMR1 premutated and mutated patients undergoing preimplantation genetic testing?
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Assisted Reproduction and Genetics"
DOI: 10.1007/s10815-020-01809-3
Abstract: To assess if the ovarian response of FMR1 premutated women undergoing preimplantation genetic testing (PGT) for Fragile X syndrome is lower compared with fully mutated patients, due to their frequent premature ovarian failure. In a… read more here.
Keywords: fmr1 premutated; ovarian response; mutated patients; undergoing preimplantation ... See more keywords
Higher antitumor activity of trabectedin in germline BRCA2 carriers with advanced breast cancer as compared to BRCA1 carriers: A subset analysis of a dedicated phase II trial.
Sign Up to like & getrecommendations! Published in 2017 at "Breast"
DOI: 10.1016/j.breast.2017.04.006
Abstract: Specific alkylators may allow synthetic lethality among patients with germline BRCA1/2-mutations related cancers. The tetrahydroisoquinolone trabectedin administered at 1.3 mg/m2 as a 3-h intravenous infusion every 3 weeks showed activity in patients with pretreated metastatic breast… read more here.
Keywords: mutated patients; brca2 carriers; brca2 mutated; brca2 ... See more keywords
Additional mutations in IDH1/2-mutated patients with acute myeloid leukemia.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of laboratory hematology"
DOI: 10.1111/ijlh.13648
Abstract: OBJECTIVE Somatic mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) frequently emerge in acute myeloid leukemia (AML), but the clinical features and molecular characteristics of IDH mutational status and other coexisting mutations have… read more here.
Keywords: mutated patients; idh1 idh2; myeloid leukemia; acute myeloid ... See more keywords
Favorable Immune Microenvironment in Patients with EGFR and MAPK Co-Mutations
Sign Up to like & getrecommendations! Published in 2020 at "Lung Cancer: Targets and Therapy"
DOI: 10.2147/lctt.s262822
Abstract: Purpose Although EGFR-mutated patients generally do not benefit from checkpoint inhibitors (ICIs), some patients in the KEYNOTE-001 study consistently benefited from this treatment. This study investigated immune microenvironment characteristics to identify the subgroup of patients… read more here.
Keywords: immune microenvironment; mutated patients; egfr mapk; mapk mutations ... See more keywords
Clinical and Molecular Features of KRAS-Mutated Lung Cancer Patients Treated with Immune Checkpoint Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14194933
Abstract: Simple Summary The molecular and clinical features of KRAS-mutated lung cancer patients treated with immunotherapy have yet to be well characterized, and little information is known about resistance in these patients. The goal of this… read more here.
Keywords: lung cancer; mutated patients; kras mutated; features kras ... See more keywords
Outcomes of Patients with Metastatic Castration-Resistant Prostate Cancer According to Somatic Damage DNA Repair Gene Alterations
Sign Up to like & getrecommendations! Published in 2022 at "Current Oncology"
DOI: 10.3390/curroncol29040226
Abstract: (1) Background: In literature, approximately 20% of mCRPC present somatic DNA damage repair (DDR) gene mutations, and their relationship with response to standard therapies in mCRPC is not well understood. The objective was to evaluate… read more here.
Keywords: dna; according somatic; damage; mutated patients ... See more keywords