Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Kinase with Application as an Anticancer Agent.
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DOI: 10.1021/acs.jmedchem.8b01187
Abstract: The kinase ataxia telangiectasia mutated and rad3 related (ATR) is a key regulator of the DNA-damage response and the apical kinase which orchestrates the cellular processes that repair stalled replication forks (replication stress) and associated… read more here.
Keywords: inhibitor; kinase; ataxia telangiectasia; rad3 related ... See more keywords
Design, Synthesis, and Biological Evaluation of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3-Related (ATR) Kinase for the Efficient Treatment of Cancer
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DOI: 10.3390/molecules28114521
Abstract: Ataxia telangiectasia mutated and Rad3-related (ATR), a vital member of the phosphatidylinositol 3-kinase-related kinase (PIKK) family, plays a critical role in the DNA damage response (DDR). Tumor cells with a loss of DDR function or… read more here.
Keywords: ataxia telangiectasia; rad3 related; related atr; telangiectasia mutated ... See more keywords