Self-Internal-Reference Probe System for Control-Free Quantification of Mutation Abundance.
Sign Up to like & getrecommendations! Published in 2021 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c02877
Abstract: Gene mutations are important biomarkers for the diagnosis, classification, monitoring, and prognosis evaluation of cancers and genetic diseases. Both personalized cancer treatment and noninvasive prenatal testing require methods to accurately determine the abundance of mutation.… read more here.
Keywords: system; probe; mutation abundance; internal reference ... See more keywords
Can mutation abundance assess the biological behavior of BRAFV600E-positive papillary thyroid carcinoma?
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-025-06493-4
Abstract: BRAFV600E mutation is the most common genetic change in papillary thyroid carcinoma (PTC). Nevertheless, the association between BRAFV600E mutation status and abundance and the biological behavior of PTC is unclear. Thus, this study investigated whether… read more here.
Keywords: abundance; mutation abundance; brafv600e mutation; model ... See more keywords