New complexities of SOS-induced "untargeted" mutagenesis in Escherichia coli as revealed by mutation accumulation and whole-genome sequencing.
Sign Up to like & getrecommendations! Published in 2020 at "DNA repair"
DOI: 10.1016/j.dnarep.2020.102852
Abstract: When its DNA is damaged, Escherichia coli induces the SOS response, which consists of about 40 genes that encode activities to repair or tolerate the damage. Certain alleles of the major SOS-control genes, recA and… read more here.
Keywords: sos induced; whole genome; escherichia coli; mutation accumulation ... See more keywords
Trends of mutation accumulation across global SARS-CoV-2 genomes: Implications for the evolution of the novel coronavirus
Sign Up to like & getrecommendations! Published in 2020 at "Genomics"
DOI: 10.1016/j.ygeno.2020.11.003
Abstract: To understand SARS-CoV-2 microevolution, this study explored the genome-wide frequency, gene-wise distribution, and molecular nature of all point-mutations detected across its 71,703 RNA-genomes deposited in GISAID till 21 August 2020. Globally, nsp1/nsp2 and orf7a/orf3a were… read more here.
Keywords: accumulation across; across global; trends mutation; mutation accumulation ... See more keywords
Germline mutation rates in young adults predict longevity and reproductive lifespan
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-66867-0
Abstract: Ageing may be due to mutation accumulation across the lifespan, leading to tissue dysfunction, disease, and death. We tested whether germline autosomal mutation rates in young adults predict their remaining survival, and, for women, their… read more here.
Keywords: germline mutation; mutation; mutation accumulation; mutation rates ... See more keywords
Fitness Effects of Mutations: An Assessment of PROVEAN Predictions Using Mutation Accumulation Data
Sign Up to like & getrecommendations! Published in 2022 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evac004
Abstract: Abstract Predicting fitness in natural populations is a major challenge in biology. It may be possible to leverage fast-accumulating genomic data sets to infer the fitness effects of mutant alleles, allowing evolutionary questions to be… read more here.
Keywords: fitness effects; biology; mutation accumulation; fitness ... See more keywords
Mode and Tempo of Microsatellite Length Change in a Malaria Parasite Mutation Accumulation Experiment
Sign Up to like & getrecommendations! Published in 2019 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evz140
Abstract: Abstract Malaria parasites have small extremely AT-rich genomes: microsatellite repeats (1–9 bp) comprise 11% of the genome and genetic variation in natural populations is dominated by repeat changes in microsatellites rather than point mutations. This… read more here.
Keywords: malaria; experiment; repeat; mutation accumulation ... See more keywords
Spontaneous Mutation Accumulation in Daphnia pulex in Selection-Free vs. Competitive Environments
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msw234
Abstract: Understanding the rates, spectra, and fitness effects of spontaneous mutations is fundamental to answering key questions in evolution, molecular biology, disease genetics, and conservation biology. To estimate mutation rates and evaluate the effect of selection… read more here.
Keywords: daphnia pulex; biology; mutation accumulation; selection ... See more keywords
Mutation accumulation opposes polymorphism: supergenes and the curious case of balanced lethals
Sign Up to like & getrecommendations! Published in 2022 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2021.0199
Abstract: Supergenes offer spectacular examples of long-term balancing selection in nature, but their origin and maintenance remain a mystery. Reduced recombination between arrangements, a critical aspect of many supergenes, protects adaptive multi-trait phenotypes but can lead… read more here.
Keywords: balanced lethal; polymorphism; lethal systems; mutation ... See more keywords
Identification of natural product 3, 5-diiodotyrosine as APOBEC3B inhibitor to prevent somatic mutation accumulation and cancer progression
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-005503
Abstract: Background The development of cancer is largely dependent on the accumulation of somatic mutations, indicating the potential to develop cancer chemoprevention agents targeting mutation drivers. However, ideal cancer chemoprevention agents that can effectively inhibit the… read more here.
Keywords: somatic mutation; mutation accumulation; cancer; diiodotyrosine ... See more keywords
Abstract 135: Elucidating tumor evolution in pediatric cancers using stochastic models and mutation accumulation experiments
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-135
Abstract: Ontology-based approaches have been utilized for identifying cancer genes. However, among the thousands of mutations in pediatric cancer genes, accurate prediction of driver genes is one of the biggest challenges. A binary logistic regression model… read more here.
Keywords: cancer; stochastic models; using stochastic; accumulation experiments ... See more keywords