Oncogenic G12D mutation alters local conformations and dynamics of K-Ras
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-48029-z
Abstract: K-Ras is the most frequently mutated oncoprotein in human cancers, and G12D is its most prevalent mutation. To understand how G12D mutation impacts K-Ras function, we need to understand how it alters the regulation of… read more here.
Keywords: mutation alters; local conformations; oncogenic g12d; g12d mutation ... See more keywords
LRRK2 mutation alters behavioral, synaptic and non-synaptic adaptations to acute social stress.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of neurophysiology"
DOI: 10.1152/jn.00137.2020
Abstract: Parkinson's disease (PD) risk is increased by stress and certain gene mutations, including the most prevalent PD-linked mutation LRRK2-G2019S. Both PD and stress increase risk for psychiatric symptoms, yet it is unclear how PD-risk genes… read more here.
Keywords: mutation alters; lrrk2 mutation; stress induced; stress ... See more keywords