Erythrocyte-Based Pig-a Gene Mutation Assay.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9646-9_2
Abstract: In addition to chromosomal damage, assessment of gene mutation is an important part of genotoxicity testing employed during preclinical safety testing. The Pig-a gene mutation assay is based on the loss of function of the… read more here.
Keywords: pig gene; erythrocyte based; mutation assay; gene mutation ... See more keywords
Development of a novel PIG-A gene mutation assay based on a GPI-anchored fluorescent protein sensor
Sign Up to like & getrecommendations! Published in 2019 at "Genes and Environment"
DOI: 10.1186/s41021-019-0135-6
Abstract: BackgroundAccumulation of somatic mutations caused by both endogenous and exogenous exposures is a high risk for human health, in particular, cancer. Efficient detection of somatic mutations is crucial for risk assessment of different types of… read more here.
Keywords: pig; mutation assay; gpi; gene ... See more keywords