Determining the Mutation Bias of Favipiravir in Influenza Virus Using Next-Generation Sequencing
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Virology"
DOI: 10.1128/jvi.01217-18
Abstract: New antiviral drugs are needed as a first line of defense in the event of a novel influenza pandemic. Favipiravir is a broad-spectrum antiviral which is effective against influenza. The exact mechanism of how favipiravir… read more here.
Keywords: mutation bias; influenza; bias; next generation ... See more keywords
Mutation bias interacts with composition bias to influence adaptive evolution
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1008296
Abstract: Mutation is a biased stochastic process, with some types of mutations occurring more frequently than others. Previous work has used synthetic genotype-phenotype landscapes to study how such mutation bias affects adaptive evolution. Here, we consider… read more here.
Keywords: composition bias; adaptive evolution; bias; mutation ... See more keywords