Unexpected UVR and non-UVR mutation burden in some acral and cutaneous melanomas
Sign Up to like & getrecommendations! Published in 2017 at "Laboratory Investigation"
DOI: 10.1038/labinvest.2016.143
Abstract: Ultraviolet radiation (UVR) mutagenesis causes nearly all cutaneous melanomas, however, since UVR signatures are largely absent in acral melanoma, as well as melanoma in sun-protected sites, the cause of these melanomas is unknown. Whole-genome sequencing… read more here.
Keywords: melanomas; non uvr; mutation burden; cutaneous melanomas ... See more keywords
Lung Cancer: Frontline nivolumab — CheckMate 026 ends in stalemate
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Clinical Oncology"
DOI: 10.1038/nrclinonc.2017.102
Abstract: is an approved second-line therapy for advanced-stage non-small-cell lung cancer (NSCLC), but earlier use of this immunotherapeutic agent might be beneficial. In the phase III CheckMate 026 trial, David Carbone et al. addressed this question.… read more here.
Keywords: mutation burden; checkmate 026; frontline nivolumab; lung cancer ... See more keywords
Rate volatility and asymmetric segregation diversify mutation burden in cells with mutator alleles
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-020-01544-6
Abstract: Mutations that compromise mismatch repair (MMR) or DNA polymerase ε or δ exonuclease domains produce mutator phenotypes capable of fueling cancer evolution. Here, we investigate how combined defects in these pathways expands genetic heterogeneity in… read more here.
Keywords: asymmetric segregation; rate; mutation burden; diversify mutation ... See more keywords
Comprehensive analysis of tumor mutation burden and immune microenvironment in gastric cancer
Sign Up to like & getrecommendations! Published in 2021 at "Bioscience Reports"
DOI: 10.1042/bsr20203336
Abstract: Abstract Tumor mutation burden (TMB) was a promising marker for immunotherapy. We aimed to investigate the prognostic role of TMB and its relationship with immune cells infiltration in gastric cancer (GC). We analyzed the mutation… read more here.
Keywords: infiltration; mutation burden; gastric cancer; tumor mutation ... See more keywords
Tumour mutation burden analysis in a 5660-cancer-patient cohort reveals cancer type-specific mechanisms for high mutation burden
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdz431.007
Abstract: Abstract Background In this study, we examined the TMB landscape of 5,660 pan-cancer cases in Chinese population, using NGS panel. We established cancer-specific and histology-specific biological pathways associated with the TMB status. In addition, as… read more here.
Keywords: cancer; mutation burden; tmb; histology ... See more keywords
Mutation Burden Analysis of Six Common Mental Disorders in African Americans by Whole Genome Sequencing.
Sign Up to like & getrecommendations! Published in 2022 at "Human molecular genetics"
DOI: 10.1093/hmg/ddac129
Abstract: Mental disorders present a global health concern, with limited treatment options. In today's medical practice, medications such as antidepressants are prescribed not only for depression, but also for conditions such as anxiety and attention deficit… read more here.
Keywords: mental disorders; african americans; mutation burden; burden analysis ... See more keywords
Clinical significance of tumour mutation burden in immunotherapy across multiple cancer types: an individual meta-analysis.
Sign Up to like & getrecommendations! Published in 2020 at "Japanese journal of clinical oncology"
DOI: 10.1093/jjco/hyaa076
Abstract: BACKGROUND Biomarkers for stratifying patients that could benefit from immune checkpoint inhibitors are necessary. Tumour mutation burden has recently become a promising biomarker in cancer, but the associations between tumour mutation burden and outcomes of… read more here.
Keywords: cancer; tumour mutation; mutation burden; meta analysis ... See more keywords
Decoding tumor mutation burden and driver mutations in early stage lung adenocarcinoma using CT‐based radiomics signature
Sign Up to like & getrecommendations! Published in 2019 at "Thoracic Cancer"
DOI: 10.1111/1759-7714.13163
Abstract: Tumor mutation burden (TMB) is an important determinant and biomarker for response of targeted therapy and prognosis in patients with lung cancer. The present study aimed to determine whether radiomics signature could non‐invasively predict the… read more here.
Keywords: radiomics signature; tumor mutation; driver mutations; stage lung ... See more keywords
A lncRNA prognostic signature associated with immune infiltration and tumour mutation burden in breast cancer
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15762
Abstract: Current studies have shown that long non‐coding RNAs (lncRNAs) may serve as prognostic biomarkers in multiple cancers. Therefore, we postulated that expression patterns of multiple lncRNAs combined into a single signature could improve clinicopathological risk… read more here.
Keywords: tumour mutation; breast cancer; mutation burden; signature ... See more keywords
Integrative Modeling of Multiomics Data for Predicting Tumor Mutation Burden in Patients with Lung Cancer
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/2698190
Abstract: Immunotherapy has been widely used in the treatment of lung cancer, and one of the most effective biomarkers for the prognosis of immunotherapy currently is tumor mutation burden (TMB). Although whole-exome sequencing (WES) could be… read more here.
Keywords: lung cancer; tumor mutation; mutation burden; model ... See more keywords
Hypoxia Confers Tumor with a Higher Immune Infiltration but Lower Mutation Burden in Gastrointestinal Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/4965167
Abstract: Background Hypoxia is one of the driving forces of cancer progression, recurrence, and metastasis. However, the association between the tumor hypoxic tumor microenvironment and the tumor mutation burden (TMB) is poorly understood in gastrointestinal cancer.… read more here.
Keywords: mutation burden; immune infiltration; gastrointestinal cancer; cancer ... See more keywords