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Mutation-Driven Therapy in MDS

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0 Published in 2019 at "Current Hematologic Malignancy Reports"

DOI: 10.1007/s11899-019-00554-4

Abstract: Genetic sequencing in myelodysplastic syndrome (MDS) has provided an improved understanding of the complexity and heterozygosity of the disease. More importantly, our molecular understanding of MDS is leading to rapid advancements and personalized therapy for… read more here.

Keywords: mutation driven; therapy mds; driven therapy; therapy ... See more keywords

Chaos-Induced and Mutation-Driven Schemes Boosting Salp Chains-Inspired Optimizers

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0 Published in 2019 at "IEEE Access"

DOI: 10.1109/access.2019.2902306

Abstract: Salp swarm algorithm (SSA) is a newly developed meta-heuristic algorithm, which is mainly developed based on the swarming behavior of salps sailing and foraging in the ocean. An improved salp swarm-based optimizer is proposed in… read more here.

Keywords: driven schemes; mutation; mutation driven; chaos induced ... See more keywords

Mutation-driven evolution of antibacterial function in an ancestral antifungal scaffold: Significance for peptide engineering

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1 Published in 2022 at "Frontiers in Microbiology"

DOI: 10.3389/fmicb.2022.1053078

Abstract: Mutation-driven evolution of novel function on an old gene has been documented in many development- and adaptive immunity-related genes but is poorly understood in immune effector molecules. Drosomycin-type antifungal peptides (DTAFPs) are a family of… read more here.

Keywords: function; antibacterial function; driven evolution; mutation driven ... See more keywords

Mutation-Driven Signals of ARID1A and PI3K Pathways in Ovarian Carcinomas: Alteration Is An Opportunity

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1 Published in 2019 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms20225732

Abstract: The chromosome is a functionally dynamic structure. The dynamic nature of chromosome functionally connects it to almost every event within a cell, in health and sickness. Chromatin remodeling system acts in unison with the cell… read more here.

Keywords: driven signals; ovarian carcinomas; mutation driven; opportunity ... See more keywords

Mutation-Driven S100A8 Overexpression Confers Aberrant Phenotypes in Type 1 CALR-Mutated MPN

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1 Published in 2023 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24108747

Abstract: Numerous pathogenic CALR exon 9 mutations have been identified in myeloproliferative neoplasms (MPN), with type 1 (52bp deletion; CALRDEL) and type 2 (5bp insertion; CALRINS) being the most prevalent. Despite the universal pathobiology of MPN… read more here.

Keywords: mutated mpn; calr; s100a8 overexpression; driven s100a8 ... See more keywords