Mutation and evolution of metallo-beta-lactamase CphA under the selective pressure of biapenem continuous concentration gradient.
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DOI: 10.1016/j.jinorgbio.2022.111776
Abstract: One of the resistance mechanisms of superbugs is to hydrolyze antibiotics by producing metallo-β-lactamases (MβLs). To verify how MβLs evolved to increase in activity in response to various β-lactam antibiotics, the mutation and evolution of… read more here.
Keywords: cpha; metallo; mutation evolution; binding pocket ... See more keywords