Variable mutation expression in human cancers: A 'hide-and-seek' mechanism linked to differential MHC-I presentation dynamics.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular cancer therapeutics"
DOI: 10.1158/1535-7163.mct-21-0831
Abstract: Not all genomic mutations are expressed at the transcript/protein level, which may explain variation in cancer development, prognosis, and treatment response/resistance. In this study, our aim was to describe the prevalence of somatic mutation loss… read more here.
Keywords: mhc; mutation expression; variable mutation; expression ... See more keywords
Comprehensive analysis of mutation and expression based pathways in head and neck squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e18015
Abstract: e18015Background: Over- or under expression of mRNA result from genetic alteration. mRNA expression based pathway are as important as single gene level mutations analyzed by next generation sequenc... read more here.
Keywords: expression based; comprehensive analysis; mutation expression; expression ... See more keywords