Microsatellite mutation frequencies in river otters (Lontra Canadensis) from the Athabasca Oil Sands region are correlated to polycyclic aromatic compound tissue burden
Sign Up to like & getrecommendations! Published in 2022 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22482
Abstract: Mining activities in the Athabasca oil sands region (AOSR) have contributed to an increase of polycyclic aromatic compounds (PACs) locally. However, many PACs found in the AOSR, and the combined effects of PAC mixtures have… read more here.
Keywords: river otters; mutation frequency; microsatellite mutation; mutation frequencies ... See more keywords
Predictive Value of the TP53 p.G245S Mutation Frequency for the Short-Term Recurrence of Hepatocellular Carcinoma as Detected by Pyrophosphate Sequencing.
Sign Up to like & getrecommendations! Published in 2022 at "Genetic testing and molecular biomarkers"
DOI: 10.1089/gtmb.2022.0032
Abstract: Aims: We explored the relationship between the mutation of the p.G245S site in TP53 and the short-term recurrence of hepatocellular carcinoma (HCC). Materials and Methods: One hundred one HCC patients were included in this study.… read more here.
Keywords: g245s mutation; mutation frequency; recurrence; mutation ... See more keywords
Increased mtDNA mutation frequency in oocytes causes epigenetic alterations and embryonic defects
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DOI: 10.1093/nsr/nwac136
Abstract: Abstract Mitochondria are essential for female reproductive processes, yet the function of mitochondrial DNA (mtDNA) mutation in oocytes remains elusive. By employing an mtDNA mutator (Polgm) mouse model, we found the fetal growth retardation and… read more here.
Keywords: frequency oocytes; mtdna mutation; mutation frequency; increased mtdna ... See more keywords
Genes and Proteomes Associated With Increased Mutation Frequency and Multidrug Resistance of Naturally Occurring Mismatch Repair-Deficient Salmonella Hypermutators
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DOI: 10.3389/fmicb.2020.00770
Abstract: The emergence of antibiotic-resistant Salmonella through mutations led to mismatch repair (MMR) deficiency that represents a potential hazard to public health. Here, four representative MMR-deficient Salmonella hypermutator strains and Salmonella Typhimurium LT2 were used to… read more here.
Keywords: mutation frequency; resistance; mutation; deficient salmonella ... See more keywords