IDH mutation in glioma: molecular mechanisms and potential therapeutic targets
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Cancer"
DOI: 10.1038/s41416-020-0814-x
Abstract: Isocitrate dehydrogenase (IDH) enzymes catalyse the oxidative decarboxylation of isocitrate and therefore play key roles in the Krebs cycle and cellular homoeostasis. Major advances in cancer genetics over the past decade have revealed that the… read more here.
Keywords: mutation; glioma molecular; molecular mechanisms; idh mutation ... See more keywords
IDH Inhibitors Target Common Mutation in Glioma.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-nd2019-007
Abstract: Mutant-selective IDH1 inhibitors engage their target in the brain and shrink glioma tumors with an acceptable safety profile, according to phase I trial data on three different drug candidates. However, some clinicians argue the drug… read more here.
Keywords: target common; inhibitors target; glioma; mutation glioma ... See more keywords