Impact of A2V Mutation and Histidine Tautomerism on Aβ42 Monomer Structures from Atomistic Simulations
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DOI: 10.1021/acs.jcim.0c00267
Abstract: Self-assembly of amyloid-β (Aβ) peptides into senile plaques in the brain is a hallmark of Alzheimer's disease (AD) pathology. Mutation and histidine tautomerism are considered intrinsic origins in accumulation of Aβ. As a first step… read more here.
Keywords: tautomerism; impact a2v; histidine tautomerism; mutation histidine ... See more keywords