Identification of Local Clusters of Mutation Hotspots in Cancer-Related Genes and Their Biological Relevance
Sign Up to like & getrecommendations! Published in 2019 at "IEEE/ACM Transactions on Computational Biology and Bioinformatics"
DOI: 10.1109/tcbb.2018.2813375
Abstract: Mutation hotspots are either solitary amino acid residues or stretches of amino acids that show elevated mutation frequency in cancer-related genes, but their prevalence and biological relevance are not completely understood. Here, we developed a… read more here.
Keywords: mutation hotspots; related genes; cancer related; biological relevance ... See more keywords
Elevated pyrimidine dimer formation at distinct genomic bases underlies promoter mutation hotspots in UV-exposed cancers
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DOI: 10.1371/journal.pgen.1007849
Abstract: Sequencing of whole cancer genomes has revealed an abundance of recurrent mutations in gene-regulatory promoter regions, in particular in melanoma where strong mutation hotspots are observed adjacent to ETS-family transcription factor (TF) binding sites. While… read more here.
Keywords: mutation hotspots; elevated pyrimidine; promoter mutation; formation ... See more keywords
The Mutation Hotspots at UGT1A Locus May Be Associated with Gilbert’s Syndrome Affecting the Taiwanese Population
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DOI: 10.3390/ijms232012709
Abstract: Gilbert’s syndrome is mainly diagnosed through genetic analysis and is primarily detected through a mutation in the promoter region of the UGT1A1 gene. However, most of the research has been conducted on Caucasian populations. In… read more here.
Keywords: syndrome; mutation hotspots; gilbert syndrome; taiwanese population ... See more keywords